Understanding membrane remodelling initiated by photosensitized lipid oxidation

Autor(es)

Tsubone, Tayana Mazin ^[1] ; Baptista, Mauricio S. ^[2] ; Itri, Rosangela ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Phys, Appl Phys Dept, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Inst Chem, Biochem Dept, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Biophysical Chemistry; v. 254, NOV 2019.
• Citações Web of Science: 2

Resumo

In this review, we describe how photooxidation changes membrane properties that can ultimately lead to permanent membrane damage. Lipid photooxidation occurs in the presence of reactive oxygen species such as singlet oxygen and by direct reactions of lipids with a photosensitizer in the excited state. Indeed, lipid oxidation triggers chemical transformations that can alter lipid packing; change the membrane surface area, thickness and elastic modulus; and induce pore formation and phase separation. Here, we highlight how lipid hydroperoxides promote membrane remodelling and phase separation. Further, we emphasize the alterations caused by truncated oxidized lipids that lead to increased membrane permeability. Finally, the consequences of lipid photooxidation on cell functions are also discussed. (AU)

• Processo FAPESP: 14/20107-7 - Oxidação lipídica em biofísica de membranas e celular: de nanosensores funcionais ao impacto sobre a formação de amiloides. Aplicação de técnicas avançadas de fluorescência, espalhamento de RX e microscopias
• Beneficiário: Rosangela Itri
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/23071-9 - Fotossensibilização em membranas miméticas lisossomais para investigação do mecanismo de morte celular associada a autofagia.
• Beneficiário: Tayana Mazin Tsubone
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado