The modulatory effect of triclosan on the reversion of the activated phenotype of LX-2 hepatic stellate cells

Autor(es)

Miranda, Juliana F. ^[1] ; Scarinci, Leticia D. ^[1] ; Ramos, Leticia F. ^[1] ; Silva, Caio M. ^[1] ; Goncalves, Leticia R. ^[1] ; de Morais, Priscila F. ^[1] ; Malaspina, Osmar ^[2] ; Moraes, Karen C. M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Dept Biol, Inst Biociencias, Campus Rio Claro, Rio Claro, SP - Brazil

^[2] Univ Estadual Paulista, Ctr Estudos Insetos Sociais, Inst Biociencias, Rio Claro, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY; v. 34, n. 1 JAN 2020.
• Citações Web of Science: 0

Resumo

Hepatic diseases leading to fibrosis affect millions of individuals worldwide and are a major public health challenge. Although, there have been many advances in understanding hepatic fibrogenesis, an effective therapy remains elusive. Studies focus primarily on activation of the hepatic stellate cells (HSCs), the principal fibrogenic cells in the liver; however, fewer numbers of studies have examined molecular mechanisms that deactivate HSC, controlling the profibrogenic phenotype. In the present study, we evaluated cellular and molecular actions of the chemical triclosan (TCS) in reverting activated HSCs to a quiesced phenotype. We demonstrated that the inhibition of the enzyme fatty acid synthase by TCS in activated HSCs promotes survival of the cells and triggers cellular and molecular changes that promote cellular phenotypic reversion, offering potentially new therapeutic directions. (AU)

• Processo FAPESP: 13/21186-5 - Redes de interações moleculares reguladas por pequenos RNAs não decodificadores no mecanismo fibrosante hepático e suas modulações pelo peptídeo vasoativo angiotensina-(1-7)
• Beneficiário: Karen Cristiane Martinez de Moraes
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/05286-3 - Análise mecanístico-funcional do microRNA 1914-5p no processo pró-esteatótico hepático não alcoólico em cultura celular
• Beneficiário: Karen Cristiane Martinez de Moraes
• Modalidade de apoio: Auxílio à Pesquisa - Regular