Novel fluoride and stannous-functionalized beta-tricalcium phosphate nanoparticles for the management of dental erosion

Autor(es)

Lira Viana, Itallo Emidio ^[1] ; Lopes, Raquel Marianna ^[1] ; Oliveira Silva, Flavia Rodrigues ^[2] ; Lima, Nelson Batista ^[2] ; Correa Aranha, Ana Cecilia ^[1] ; Feitosa, Sabrina ^[3] ; Scaramucci, Tais ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Restorat Dent, Sch Dent, Av Prof Lineu Prestes 2227, BR-05508000 Sao Paulo, SP - Brazil

^[2] Nucl & Energy Res Inst IPEN CNEN, Mat Sci & Technol Ctr, Av Prof Lineu Prestes 2242, BR-05508000 Sao Paulo, SP - Brazil

^[3] Indiana Univ, Dept Biomed Sci & Comprehens Care, Sch Dent, 1121 Michigan St, Indianapolis, IN 46202 - USA

• Tipo de documento: Artigo Científico
• Fonte: Journal of Dentistry; v. 92, JAN 2020.
• Citações Web of Science: 0

Resumo

Objective: To evaluate the anti-erosive effect of solutions containing beta-tricalcium phosphate (beta-TCP) nanoparticles functionalized with fluoride or with fluoride plus stannous on enamel and dentin. Methods: beta-TCP nanoparticles were synthesized and characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM). Sixty enamel and dentin specimens were randomly allocated into the groups (n=10): Control (water); F (NaF, 225 ppm F-); F+ Sn (NaF+SnCl2, 800 ppm Sn2+); F+beta-TCP (F+40 ppm beta-TCP); F+Sn+beta- TCP (F+Sn+40 ppm beta-TCP); F+Sn+100 beta-TCP (F+Sn+100 ppm beta-TCP). Specimens underwent erosion-remineralization cycling (5 min immersion into 1 % citric acid solution and 60 min exposure to artificial saliva, 4x/day, 5 days). Immersion in the test solutions was performed for 2 min, 2x/day. Surface loss (SL, in mu m) was determined by optical profilometry at the end of cycling. Data were analyzed using one way-ANOVA and Tukey's tests (alpha=0.05). Results: XRD confirmed the beta-TCP phase. TEM micrographs showed differences between the bare nanoparticle and the beta-TCP functionalized with F and Sn. All enamel groups presented lower SL than the control, with F + Sn, F+Sn+beta-TCP, and F+Sn+100 beta-TCP showing the lowest values. For dentin, all the groups had lower SL than the control. F+beta-TCP presented the lowest SL, significantly differing from all the other groups. Conclusion: beta-TCP nanoparticles functionalized with fluoride showed improved anti-erosive effect compared to the fluoride solution on dentin. There was no significant effect of the beta-TCP nanoparticles functionalized with fluoride plus stannous in both substrates. Clinical Relevance: beta-TCP nanoparticles are a promising agent to be added to oral health products to improve the protective effect of fluoride against dentin erosion. (AU)

• Processo FAPESP: 15/15629-7 - Análise da perda de estrutura dentinária e oclusão tubular após desafio erosivo e abrasivo com diferentes cremes dentais contendo agentes dessensibilizantes: estudo randomizado in situ
• Beneficiário: Raquel Marianna Lopes Gaona
• Modalidade de apoio: Bolsas no Brasil - Doutorado