| Texto completo | |
| Autor(es): |
Rodriguez, Benjamin
[1]
;
Nani, Joao Victor
[1, 2]
;
Almeida, Priscila G. C.
[1]
;
Brietzke, Elisa
[3]
;
Lee, Richard S.
[4]
;
Hayashi, Mirian A. F.
[1, 2]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Fed Sao Paulo UNIFESP, Dept Farmacol, Escola Paulista Med, Rua 3 Maio 100, Ed INFAR, 3rd Floor, BR-04044020 Sao Paulo, SP - Brazil
[2] Natl Inst Translat Med INCT TM, CNPq FAPESP CAPES, Ribeirao Preto - Brazil
[3] Queens Univ, Dept Psychiat, Sch Med, Kingston, ON - Canada
[4] Johns Hopkins Univ, Dept Psychiat, Baltimore, MD - USA
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS; v. 108, p. 679-693, JAN 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Schizophrenia (SCZ) is a complex psychiatric disorder with severe impact on patient's livelihood. In the last years, the importance of neuropeptides in SCZ and other CNS disorders has been recognized, mainly due to their ability to modulate the signaling of classical monoaminergic neurotransmitters as dopamine. In addition, a class of enzymes coined as oligopeptidases are able to cleave several of these neuropeptides, and their potential implication in SCZ was also demonstrated. Interestingly, these enzymes are able to play roles as modulators of neuropeptidergic systems, and they were also implicated in neurogenesis, neurite outgrowth, neuron migration, and therefore, in neurodevelopment and brain formation. Altered activity of oligopeptidases in SCZ was described only more recently, suggesting their possible utility as biomarkers for mental disorders diagnosis or treatment response. We provide here an updated and comprehensive review on neuropeptides and oligopeptidases involved in mental disorders, aiming to attract the attention of physicians to the potential of targeting this system for improving the therapy and for understanding the neurobiology underlying mental disorders as SCZ. (AU) | |
| Processo FAPESP: | 14/50867-3 - INCT 2014: Instituto Nacional de Ciência e Tecnologia de Bioanalítica |
| Beneficiário: | Marco Aurelio Zezzi Arruda |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 14/50891-1 - INCT 2014: Translacional em Medicina |
| Beneficiário: | Jaime Eduardo Cecilio Hallak |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 17/02413-1 - Validação da crotamina como biomarcador e avaliação do seu potencial uso na terapia de doenças humanas |
| Beneficiário: | Mirian Akemi Furuie Hayashi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 14/18938-8 - Ressonância magnética nuclear aplicada em análises metabolômicas de pacientes e em modelos animais para os transtornos mentais graves |
| Beneficiário: | Ljubica Tasic |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 19/09207-3 - Estudo do(s) mecanismo(s) molecular(es) e celular(es) em transtornos mentais |
| Beneficiário: | João Victor Silva Nani |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |