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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Action mechanisms of probiotics on Candida spp. and candidiasis prevention: an update

Texto completo
Autor(es):
Ribeiro, F. C. [1] ; Rossoni, R. D. [1] ; de Barros, P. P. [1] ; Santos, J. D. [1] ; Fugisaki, L. R. O. [1] ; Leao, M. P. V. [2] ; Junqueira, J. C. [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Dept Biosci & Oral Diag, Inst Sci & Technol, Sao Jose Dos Campos, SP - Brazil
[2] Univ Taubate, Biosci Basic Inst, Taubate, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: Journal of Applied Microbiology; v. 129, n. 2 NOV 2019.
Citações Web of Science: 1
Resumo

Due to the high incidence of fungal infections caused by Candida species and their increasing resistance to antimicrobial treatments, alternative therapies such as probiotics have been studied. It has been show that several species of the genus Lactobacillus have anti-Candida activity, probably by direct inhibition, through competition for adhesion sites or production of secondary metabolites, and by indirect inhibition, through stimulation of the immune system of their host. However, the mechanisms of inhibition of these probiotics on Candida species have not yet been fully elucidated since this effect is related to more than one inhibition pathway. In the literature, several in vitro and in vivo studies have been developed seeking to elucidate the probiotics mechanisms of action. These studies have been focused on C. albicans inhibition assays, including analysis of antimicrobial activity, adherence capacity, biofilms formation, filamentation and interference on virulence genes, as well as assays of experimental candidiasis in invertebrate and vertebrate models. In this context, the purpose of this review was to gather different studies focused on the action mechanism of probiotic strains on Candida sp. and to discuss their impact on the candidiasis prevention. (AU)

Processo FAPESP: 17/19219-3 - Identificação de substâncias bioativas produzidas por Lactobacillus paracasei 28.4 para o controle da candidose bucal
Beneficiário:Rodnei Dennis Rossoni
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 16/25544-1 - Desenvolvimento de formulações probióticas para a prevenção da candidose bucal: Estudo in vitro e in vivo
Beneficiário:Felipe de Camargo Ribeiro
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 17/02652-6 - Avaliação dos efeitos imunomodulatórios e antifúngicos do ácido caféico (CA), do éster fenetil do ácido caféico (CAPE) e da artepillin C (ARC) sobre C. albicans e desenvolvimento de candidose em modelos hospedeiros in vivo
Beneficiário:Patricia Pimentel de Barros
Linha de fomento: Bolsas no Brasil - Pós-Doutorado