Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Molluscicidal and cercaricidal activities of curcumin on Biomphalaria glabrata and Schistosoma mansoni cercariae

Texto completo
Autor(es):
Matos, Jaqueline L. [1] ; da Silva, Karen R. [1] ; de Lima Paula, Lucas A. [1] ; Cunha, Wilson R. [1] ; Ramos, Salvador B. [2] ; Rodrigues, Vanderlei [3] ; Cabral, Fernanda J. [4] ; Magalhaes, Lizandra G. [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Franca, Ctr Res Sci & Technol, Res Grp Nat Prod, Ave Dr Armando Salles Oliveira 201, Franca, SP - Brazil
[2] Univ Franca, Dept Hlth Promot, Franca - Brazil
[3] Univ Sao Paulo, Coll Med Ribeirao Preto, Dept Biochem & Immunol, Ribeirao Preto - Brazil
[4] Univ Estadual Campinas, Inst Biol, Dept Anim Biol, R Monteiro Lobato St 255, Campinas, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Pest Management Science; NOV 2019.
Citações Web of Science: 0
Resumo

BACKGROUND Schistosomiasis control in endemic areas depends on several factors, including chemotherapy, snail control and adequate sanitation. In this context, the employment of compounds isolated from plants is an important issue regarding infection and snail control. The aim of this study was therefore to evaluate the effects of curcumin (CUR), a compound isolated from Curcuma longa, against snails and embryos of Biomphalaria glabrata, which is the most important intermediate host of schistosomiasis in the Americas, as well as in cercariae, the infecting larval stage of Schistosoma mansoni. RESULTS CUR presented high activity against B. glabrata embryos and moderate activity against newborn and adult snails. The lethal concentration (LC50) values after being exposed for 24 h and evaluated for 7 days were 6.54 (95% confidence interval (CI) 5.86-7.30) mu g mL(-1) for the embryos and 42.29 (95% CI 33.82-52.87) mu g mL(-1) and 87.69 (95% CI 68.82-111.7) mu g mL(-1) for the newborn and adult snails, respectively. Moreover, CUR inhibited the development of embryos and egg hatching, and decreased the fecundity rates of adult snails. CUR also demonstrated cercaricidal activity with LC50 values lower than 10 mu g mL(-1) at 1, 3, 6, 9 and 12 h, respectively. CONCLUSION Our data show that CUR has potential molluscicidal and cercaricidal activities. Moreover, as a nutraceutical compound that is toxic to both invertebrate host and parasite, CUR has the potential to be explored as a safe new agent to combat schistosomiasis. (c) 2019 Society of Chemical Industry (AU)

Processo FAPESP: 13/11164-4 - Avaliação da indução da apoptose em vermes adultos de Schistosoma mansoni após exposição com curcumina
Beneficiário:Lizandra Guidi Magalhães
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/24456-1 - Curcuminóides monocetônicos para o tratamento da esquistossomose: uma avaliação pré-clínica da atividade esquistossomicida
Beneficiário:Lizandra Guidi Magalhães
Linha de fomento: Auxílio à Pesquisa - Regular