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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Human platelet antigen polymorphisms and the risk of chronic Chagas disease cardiomyopathy

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Autor(es):
do Carmo Correa, Deborah Elzita [1] ; Ayo, Christiane Maria [2] ; Laguila Visentainer, Jeane Eliete [1] ; Ambrosio-Albuquerque, Eliane Papa [3] ; Reis, Pamela Guimaraes [1] ; Brandao de Mattos, Cinara Cassia [2] ; Bestetti, Reinaldo Bulgarelli [4] ; de Mattos, Luiz Carlos [2] ; Sell, Ana Maria [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Estadual Maringa, Dept Clin Anal & Biomed, Post Grad Program Biosci & Physiopath, Maringa, Parana - Brazil
[2] Fac Med Sao Jose do Rio Preto, Dept Mol Biol, Sao Jose Do Rio Preto, SP - Brazil
[3] Univ Estadual Maringa, Dept Biotechnol Cell Biol & Genet, Maringa, Parana - Brazil
[4] Univ Ribeirao Preto, Dept Med, Ribeirao Preto, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: PLATELETS; SEP 2019.
Citações Web of Science: 0
Resumo

Human platelet antigen (HPA) polymorphisms are considered to be a risk factor for cardiac and vascular diseases, but the role of HPA in chronic Chagas disease cardiomyopathy (CCC) is not available. Therefore, the aim of this study was to investigate the association of HPA polymorphisms, HPA-1, HPA-2, HPA-3, HPA-5 and HPA-15, in the severity of left ventricular systolic dysfunction (LVSD) in CCC patients. For this, 229 CCC patients were separated into three groups: without LVSD, mild/moderate LVSD and severe LVSD. PCR-SSP was performed for HPA genotyping and the risk was assessed using SNPStats software. HPA-1 allele and genotype frequencies were lower in mild/moderate LVSD patients compared to other groups, without statistical significance. After stratified analyzes, the HPA-3a/3b genotype frequency was lower in women with severe LVSD compared to those without LVSD (OR:0.29; 95% CI: 0.10-0.84). In conclusion, HPA-3 variant could be a protection factor for CCC in the female patients. (AU)

Processo FAPESP: 13/06580-9 - Genes KIR, seus ligantes HLA e polimorfismo do gene MICA na toxoplasmose ocular e na forma digestiva da doença de Chagas
Beneficiário:Christiane Maria Ayo
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 11/08075-4 - Marcadores imunogenéticos relacionados à doença de Chagas
Beneficiário:Luiz Carlos de Mattos
Modalidade de apoio: Auxílio à Pesquisa - Regular