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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Biocompatibility and biodegradation of poly(lactic acid) (PLA) and an immiscible PLA/poly(epsilon-caprolactone) (PCL) blend compatibilized by poly(epsilon-caprolactone-b-tetrahydrofuran) implanted in horses

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Autor(es):
Carvalho, Julia R. G. [1] ; Conde, Gabriel [1] ; Antonioli, Marina L. [1] ; Dias, Paula P. [2] ; Vasconcelos, Rosemeri O. [1] ; Taboga, Sebastiao R. [3] ; Canola, Paulo A. [1] ; Chinelatto, Marcelo A. [2] ; Pereira, Gener T. [1] ; Ferraz, Guilherme C. [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Sch Agr & Veterinarian Sci FCAV, Jaboticabal, SP - Brazil
[2] Univ Sao Paulo, Sao Carlos Sch Engn EESC, Sao Carlos, SP - Brazil
[3] Sao Paulo State Univ UNESP, Inst Biosci Languages & Exact Sci IBILCE, Sao Jose Do Rio Preto, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: POLYMER JOURNAL; v. 52, n. 6 JAN 2020.
Citações Web of Science: 0
Resumo

This paper focuses on the biocompatibility and biodegradation of PLA and a recently developed PLA/PCL blend containing an in vitro nontoxic compatibilizer based on a low-molecular-weight triblock copolymer derived from epsilon-caprolactone and tetrahydrofuran. The polymers were implanted subcutaneously in the lateral surface of the neck of horses. Physical examination, plasma fibrinogen (PF) analysis, infrared thermography (IT), mechanical nociceptive threshold (MNT) analysis, and ultrasonography were performed. After 24 weeks, the biomaterials were removed for histochemical analysis using hematoxylin-eosin (HE) and picrosirius-hematoxylin (PSH) staining. Scanning electron microscopy (SEM) was employed to determine changes in the surface morphology of the PLA and PLA/PCL blend. There were no clinical or PF changes. IT indicated a transient increase in cutaneous temperature (CT), while MNT decreased after the procedure in both the implanted groups. Ultrasonography revealed edema after the procedure and the loss of echogenicity of the polymers after implantation. Both polymers elicited a foreign body response under microscopic analysis. The PSH technique revealed a fibrotic reaction with collagen deposition around the polymers. SEM showed surface roughness, suggesting a biodegradation process. In conclusion, PLA and the PLA/PCL blend were biocompatible and biodegradable, with potential for use in equine medicine. (AU)

Processo FAPESP: 17/10959-4 - Aplicabilidade de biopolímeros implantados em equinos
Beneficiário:Júlia Ribeiro Garcia de Carvalho
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 15/26738-1 - Comportamento e biomarcadores musculares de ratos submetidos à síndrome do sobretreinamento (overtraining)
Beneficiário:Guilherme de Camargo Ferraz
Linha de fomento: Auxílio à Pesquisa - Regular