Ferreira, Natalia N.
Boni, Fernanda Isadora
Ferreira, Leonardo M. B.
Reis, Rui M.
[2, 4, 3]
Gremiao, Maria Palmira D.
Número total de Autores: 7
Afiliação do(s) autor(es):
 Sao Paulo State Univ, Sch Pharmaceut Sci, UNESP, Rodovia Araraquara Jau Km 1, BR-14801902 Araraquara, SP - Brazil
 ICVS 3Bs PT Govt Associate Lab, Braga - Portugal
 Univ Minho, Sch Med, Life & Hlth Sci Res Inst ICVS, Braga - Portugal
 Barretos Canc Hosp, Mol Oncol Res Ctr, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento:
DRUG DELIVERY AND TRANSLATIONAL RESEARCH;
n. 3, SI
Citações Web of Science:
Combination therapy that uses multiple drugs against different molecular targets should be considered as interesting alternatives for treating complex diseases such as glioblastoma (GBM). Drugs like alpha-cyano-4-hydroxycinnamic acid (CHC) and the monoclonal antibody cetuximab (CTX) are already explored for their capacity to act against different hallmarks of cancer. Previous reports suggest that the simultaneous use of these drugs, as a novel combining approach, might result in additive or synergistic effects. Therefore, advances in nanotechnology-based delivery systems will inevitably bring nano-mediated therapeutic gains to the proposed combination since they enable the association of different drugs into a single carrier. The current study provides indications that the new dual therapeutic strategy proposed, in association with nanotechnology, provides significative improvements when compared to the use of isolated drugs. Nanotechnological tools were employed by developing polymeric nanoparticles based on poly(lactic-co-glycolic acid) and chitosan for CHC encapsulation. Furthermore, these structures were conjugated with CTX by supramolecular forces. In summary, the encapsulation of the CHC drug into the nanoparticles increased its individual therapeutic capacity. In addition, conjugation with CTX seemed to enhance therapeutic efficacy, especially for U251 GBM cells. In conclusion, developed nanostructured delivery systems exhibited a set of favorable attributes and potential to be applied as a promising new alternative for GBM treatment. (AU)