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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Surveillance of human retroviruses in blood samples from patients with hepatitis B and C in Sao Paulo, Brazil

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Autor(es):
Caterino-de-Araujo, Adele [1] ; Compos, Karoline Rodrigues [1] ; Boas Petrucci, Tamirez Villas [1] ; da Silva, Rafael Xavier [1] ; Lemos, Marcilio Figueiredo [2] ; Moreira, Regina Celia [2]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Secretaria Estado Saude Sao Paulo, Lab Pesquisa HTLV, Ctr Imunol, Inst Adolfo Lutz, Controle Doencas, Sao Paulo, SP - Brazil
[2] Secretaria Estado Saude Sao Paulo, Lab Hepatites, Ctr Virol, Inst Adolfo Lutz, Controle Doencas, Nucleo Doencas, Sao Paulo, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Revista da Sociedade Brasileira de Medicina Tropical; v. 53, 2020.
Citações Web of Science: 0
Resumo

Introduction: Human retroviruses and the hepatitis B and C viruses (HBV and HCV, respectively) share mutes of transmission; thus, coinfections occur and could alter subsequent disease outcomes. A preliminary study on human T-lymphotropic virus types 1 and 2 (HTLV-1/2) in serum samples from HBV- and HCV-infected individuals in Sao Paulo revealed 1.3% and 5.3% rates of coinfection, respectively. These percentages were of concern since they were detected in HTLV-endemic regions and in high-risk individuals in Brazil. The present study was conducted to extend and confirm these data. Methods: HTLV-1/2 and human immunodeficiency virus (HIV) infection status were identified in 1,984 sera for HBV and HCV viral load quantification - 1,290 samples from H13V-infected individuals (53.3% men, mean age: 47.1 years) and 694 samples from HCV-infected individuals (56.3% men, mean age: 50.1 years). HTLV-1/2 antibodies were detected by enzyme immunoassay, followed by western blotting and line immunoassay; HIV infection was detected by enzyme immunoassay. Results: HTLV-1/-2 infection was detected in 1.9% HBV-infected individuals (0.7% HTLV-1 and 1.2% HTLV-2) and in 4.0% (2.4% HTLV-1 and 1.6% HTLV-2) HCV-infected individuals; HIV infection was detected in 9.2% and 14.5%, respectively. Strong associations with HTLV and HIV, male sex, and older age were found in HBV/HTLV and HCV/HTLVcoinfected individuals (p<0.05). Conclusions: HTLV-1 and HTLV-2 were confirmed to be prevalent in individuals with HBV and HCV in Sao Paulo; coinfected individuals deserve further clinical and laboratory investigation. (AU)

Processo FAPESP: 16/03654-0 - Marcadores genéticos virais e do hospedeiro que podem influenciar o curso da infecção pelo HIV-1 e da coinfecção HIV-1/HTLV-1 e HIV-1/HTLV-2
Beneficiário:Adele Caterino de Araújo
Linha de fomento: Auxílio à Pesquisa - Regular