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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Investigation of U-251 cell death triggered by flavonoid luteolin: towards a better understanding on its anticancer property against glioblastomas

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Autor(es):
Franco, Yollanda E. M. [1] ; de Lima, Carolina A. [1] ; Rosa, Marcela N. [2] ; Silva, Viviane A. O. [2] ; Reis, Rui M. [3, 2, 4] ; Priolli, Denise G. [5] ; Carvalho, Patricia O. [5] ; do Nascimento, Jessyane R. [6] ; da Rocha, Claudia Q. [6] ; Longato, Giovanna B. [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Sao Francisco Univ Braganca Paulista, Res Lab Mol Pharmacol Bioact Cpds, Braganca Paulista, SP - Brazil
[2] Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos, SP - Brazil
[3] ICVS 3Bs PT Govt Associate Lab, Braga - Portugal
[4] Univ Minho, Sch Med, Life & Hlth Sci Res Inst ICVS, Braga - Portugal
[5] Sao Francisco Univ Braganca Paulista, Multidisciplinary Res Lab, Braganca Paulista, SP - Brazil
[6] Fed Univ Maranhao Sao Luis, Dept Chem, Lab Nat Prod, Sao Luis, Maranhao - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: NATURAL PRODUCT RESEARCH; FEB 2020.
Citações Web of Science: 0
Resumo

Recently, many studies have reported the anticancer properties of flavonoid luteolin against a variety of tumors, but there is still a lack in the description of its mechanism of action. In attempt to better contribute to the literature, we evaluated the antiproliferative activity of luteolin extracted by Fridericia platyphylla in a panel of tumor cell lines representative of six different tissues. Luteolin presented antiproliferative activity for all the assessed tumor cell lines, being glioblastoma the most sensitive one. This compound was able to inhibit U-251 cells migration and tumorigenesis. Besides, luteolin leads U-251 tumor cells to apoptosis death by depolarisation of the mitochondrial membrane, ERK proteins phosphorylation, cleavage of PARP and Caspase 9, further inducing DNA damage by H2AX phosphorylation, which had not yet been described for glioblastomas. Altogether, our results reaffirm luteolin as a potential therapeutic drug. (AU)

Processo FAPESP: 16/02345-3 - Estudo in vitro e in vivo da atividade anticâncer de flavonoides e flavonoides biomodificados
Beneficiário:Yollanda Edwirges Moreira Franco
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 16/06137-6 - Bioprospecção de compostos naturais e derivados bioativos com potencial atividade anticâncer: ensaios in vitro/in vivo e investigação do mecanismo de ação.
Beneficiário:Giovanna Barbarini Longato
Linha de fomento: Auxílio à Pesquisa - Regular