Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Study protocol to investigate biomolecular muscle profile as predictors of long-term urinary incontinence in women with gestational diabetes mellitus

Texto completo
Autor(es):
Mostrar menos -
Rudge, Marilza V. C. [1] ; Souza, Fatima P. [2] ; Abbade, Joelcio F. [1] ; Hallur, Raghavendra L. S. [1] ; Marcondes, Joao Paulo C. [1] ; Piculo, Fernanda [1, 3] ; Marini, Gabriela [4, 1] ; Vesentini, Giovana [1] ; Thabane, Lehana [5, 6] ; Witkin, Steven S. [7, 8] ; Calderon, Iracema M. P. [1] ; Barbosa, Angelica M. P. [1, 9] ; Rudge, M. V. ; Barbosa, A. M. P. ; Calderon, I. M. P. ; Souza, F. P. ; Abbade, J. F. ; Hallur, L. S. R. ; Piculo, F. ; Marini, G. ; Vesentini, G. ; Thabane, L. ; Palma, M. S. ; Graeff, C. F. O. ; Arni, R. K. ; Herculano, R. D. ; Salvadori, D. F. ; Mateus, S. ; Dal Pai Silva, M. ; Magalhaes, C. G. ; Costa, R. A. ; Lima, S. A. M. ; Felisbino, S. L. ; Barbosa, W. ; Atallah, A. ; Girao, M. J. B. ; Di Bella, Z. ; Uchoa, S. M. ; Payao, S. ; Hijas, A. ; Berghman, B. ; De Bie, R. ; Sobrevia, L. ; Junginger, B. ; Alves, F. C. B. ; Rossignoli, P. S. ; Prudencio, C. B. ; Orlandi, M. I. G. ; Goncalves, M. I. ; Nunes, S. K. ; Catinelli, B. B. ; Quiroz, S. ; Sarmento, B. V. ; Pinheiro, F. A. ; Sartorao, C. I. ; Lucas, R. R. ; Reyes, D. R. A. ; Quiroz, S. B. C. V. ; Enriquez, E. M. A. ; Oliveira, R. G. ; Floriano, J. F. ; Marcondes, J. P. C. ; Barneze, S. ; Dangio, T. D. ; Pascon, T. ; Rossignoli, P. ; Freitas, J. V. ; Takano, L. ; Reis, F. ; Caldeirao, T. D. ; Fernandes, J. N. ; Carr, A. M. ; Gaitero, M. V. C. ; Corrente, J. E. ; Nunes, H. R. C. ; Candido, A. F. ; Costa, S. M. B. ; Melo, J. V. F. ; Reis, F. V. D. S. ; Garcia, G. A. ; Rabadan, G. B. ; Bassin, H. C. M. ; Suyama, K. S. ; Damasceno, L. N. ; Takemoto, M. L. S. ; Menezes, M. D. ; Bussaneli, D. G. ; Nogueira, V. K. C. ; Lima, P. R. ; Lourenco, I. O. ; Marostica de Sa, J. ; Megid, R. A. ; Caruso, I. P. ; Rasmussen, L. T. ; Prata, G. M. ; Arantes, M. A. ; Ferraz, G. A. R. ; Camargo, L. P. ; Kron, M. R. ; Grp, Diamater Study ; Group, The Diamater Study
Número total de Autores: 101
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Botucatu Med Sch FMB, Dept Gynecol & Obstet, BR-18618687 Sao Paulo - Brazil
[2] UNESP Sao Paulo State Univ, Multiuser Ctr Biomol Innovat, Phys Dept, Inst Biosci, Sao Paulo - Brazil
[3] FIB, Physiotherapy Dept, Sao Paulo - Brazil
[4] Univ Sagrado Coracao, Bauru, SP - Brazil
[5] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON - Canada
[6] St Josephs Healthcare Hamilton, Father Sean OSullivan Res Ctr, Biostat Unit, Hamilton, ON - Canada
[7] Univ Sao Paulo, Sch Med, Inst Trop Med, Sao Paulo - Brazil
[8] Weill Cornell Med, Dept Obstet & Gynecol, New York, NY - USA
[9] UNESP Sao Paulo State Univ, Dept Physiotherapy & Occupat Therapy, Sch Philosophy & Sci, Marilia, SP - Brazil
Número total de Afiliações: 9
Tipo de documento: Artigo Científico
Fonte: BMC PREGNANCY AND CHILDBIRTH; v. 20, n. 1 FEB 19 2020.
Citações Web of Science: 0
Resumo

Background Pelvic floor muscles (PFM) and rectus abdominis muscles (RAM) of pregnant diabetic rats exhibit atrophy, co-localization of fast and slow fibers and an increased collagen type I/III ratio. However, the role of similar PFM or RAM hyperglycemic-related myopathy in women with gestational diabetes mellitus (GDM) remains poorly investigated. This study aims to assess the frequency of pelvic floor muscle disorders and pregnancy-specific urinary incontinence (PS-UI) 12 months after the Cesarean (C) section in women with GDM. Specifically, differences in PFM/RAM hyperglycemic myopathy will be evaluated. Methods The Diamater is an ongoing cohort study of four groups of 59 pregnant women each from the Perinatal Diabetes Research Centre (PDRC), Botucatu Medical School (FMB)-UNESP (Sao Paulo State University), Brazil. Diagnosis of GDM and PS-UI will be made at 24-26 weeks, with a follow-up at 34-38 weeks of gestation. Inclusion in the study will occur at the time of C-section, and patients will be followed at 24-48 h, 6 weeks and 6 and 12 months postpartum. Study groups will be classified as (1) GDM plus PS-UI; (2) GDM without PS-UI; (3) Non-GDM plus PS-UI; and (4) Non-GDM without PS-UI. We will analyze relationships between GDM, PS-UI and hyperglycemic myopathy at 12 months after C-section. The mediator variables to be evaluated include digital palpation, vaginal squeeze pressure, 3D pelvic floor ultrasound, and 3D RAM ultrasound. RAM samples obtained during C-section will be analyzed for ex-vivo contractility, morphological, molecular and OMICS profiles to further characterize the hyperglycemic myopathy. Additional variables to be evaluated include maternal age, socioeconomic status, educational level, ethnicity, body mass index, weight gain during pregnancy, quality of glycemic control and insulin therapy. Discussion To our knowledge, this will be the first study to provide data on the prevalence of PS-UI and RAM and PFM physical and biomolecular muscle profiles after C-section in mothers with GDM. The longitudinal design allows for the assessment of cause-effect relationships between GDM, PS-UI, and PFMs and RAMs myopathy. The findings may reveal previously undetermined consequences of GDM. (AU)

Processo FAPESP: 16/01743-5 - Coorte da tríade gestacional: hiperglicemia, incontinência urinária e perfil clínico, molecular e ômico da miopatia hiperglicêmica na predição de incontinência e disfunção muscular e pesquisa translacional com biodevice para regeneração muscular em ratas
Beneficiário:Marilza Vieira Cunha Rudge
Linha de fomento: Auxílio à Pesquisa - Temático