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(Referência obtida automaticamente do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Higher increase degree of FGF21 post long-term interdisciplinary weight loss therapy preserves the free fat mass and rest metabolic rate in adolescents with obesity

Texto completo
Autor(es):
Ana Claudia Pelissari Kravchychyn ; Raquel Munhoz da Silveira Campos ; Yasmin Alaby Martins Ferreira ; Sofia Emanuelle de Castro Ferreira Vicente ; Flávia Campos Corgosinho ; Lila Missae Oyama ; David Thivel ; Lian Tock ; Ana Raimunda Dâmaso
Número total de Autores: 9
Tipo de documento: Artigo Científico
Fonte: ARCHIVES OF ENDOCRINOLOGY METABOLISM; n. ahead, p. -, 2020.
Resumo

ABSTRACT Objective Fibroblast growth factor 21 (FGF21) is among the activators that can stimulate thermogenesis in the white adipose tissue and brown adipose tissue. People with obesity have elevated blood levels of FGF21, but also develop resistance to its action, impairing its beneficial role. Inversely, clinical treatments to weight loss has been pointed out as an important therapy for increasing and recovering sensitivity to FGF21. The aim was to analyse the effect of long-term weight loss interdisciplinary intervention on FGF21 and body composition. Subjects and methods Eighty-six post-pubertal obese adolescents (14-19 years-old), were submitted to 20 weeks of weight loss therapy (clinical, nutritional, psychological and physical exercise support). Anthropometric measures, body composition and rest metabolic rate (RMR) by bioelectrical impedance, and serum FGF21 sample by ELISA were evaluated. The adolescents were grouped according to FGF21 individual delta variations after therapy: Higher Increase (HI); lower increase (LI); lower decrease (LD); higher decrease (HD). Results All groups present weight loss. Only in FGF21 ≥ 76,5 pg/mL variation the free-fat-mass and rest metabolic rate were preserved and to others group these variables were significantly reduced. Conclusion High increase in FGF21 can contribute to preservation of FFM and RMR after weight loss therapy, could have important implications for energy balance regulation. Future studies are necessary to continue determining the role of magnitude effects of FGF21 levels in obesity to improve clinical practice, especially in paediatrics population. (AU)

Processo FAPESP: 15/14309-9 - Efeitos do exercício físico associado à fototerapia sobre os marcadores da adipogênese e transdiferenciação do tecido adiposo em mulheres adultas com obesidade
Beneficiário:Raquel Munhoz da Silveira Campos
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 13/08522-6 - Novas perspectivas terapêuticas na obesidade
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/50414-0 - Influência da hiperleptinemia nas respostas inflamatórias e aterogênicas em adolescentes obesos
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/53069-0 - Efeitos do tratamento multidisciplinar em adolescentes obesos com esteatose hepática não alcoólica e sua relação com as adipocitocinas pró e anti-inflamatórias
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/50356-0 - Análise de complemento protéico plasmático e de fatores de risco metabólicos em adolescentes obesos em tratamento no Centro de Recuperação e Educação Nutricional (CREN)
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular