Do different IgG repertoires play a role in B- and T-cell functional modulation during ontogeny? The ``hooks without bait{''} theory

Autor(es)

Victor, Jefferson R. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Laureate Int Univ, Div Environm Hlth, FMU, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Div Clin Dermatol, Lab Med Invest LIM 56, Ave Dr Eneas Carvalho de Aguiar 500, 3rd Floor, BR-5403000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Immunology and Cell Biology; v. 98, n. 7 APR 2020.
• Citações Web of Science: 0

Resumo

The mechanisms by which immunoglobulin (Ig)G can modulate immunity have been investigated over the past few decades. In the past three years, some studies have demonstrated that IgG can play a pivotal role in mediating complex interactions that result in functional lymphocyte modulation during maturation in self or offspring primary lymphoid organs. This effect appears to be dependent on the IgG repertoire in the absence of the influence of antigens and the functionality of diverse cell populations, including B, alpha beta T (CD4 T and CD8 T), invariant natural killer T and gamma delta T cells, in mice and humans. Based on the literature, especially on findings resulting from the therapeutic use of purified IgG (intravenous Ig) and recent pieces of evidence obtained by my group, the ``hooks without bait{''} theory is described here to guide the future development of therapies for specific immune regulation. (AU)

• Processo FAPESP: 18/05181-7 - Avaliação translacional do efeito modulador e/ou regulador dos anticorpos IgG na maturação de linfócitos TCD4, TCD8, nTreg, Tgammadelta e B intra-tímicos de neonatos.
• Beneficiário: Alberto José da Silva Duarte
• Linha de fomento: Auxílio à Pesquisa - Regular