Phylogenetic analysis of near full-length sequences of the Desmodus rotundus genetic lineage of rabies virus

Autor(es)

de Almeida Campos, Angelica Cristine ^[1] ; Romano, Camila Malta ^[2] ; Melo, Fernando Lucas ^[3] ; Araujo, Danielle Bastos ^[1] ; Sequetin Cunha, Elenice Maria ^[4] ; Veiga Sacramento, Debora Regina ^[5] ; Durigon, Edison Luiz ^[1] ; Favoretto Lazarini, Silvana Regina ^{[1, 6]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, BR-05508900 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Inst Trop Med, BR-05403000 Sao Paulo, SP - Brazil

^[3] Univ Brasilia, BR-70910900 Brasilia, DF - Brazil

^[4] Biol Inst Sao Paulo State, BR-04014002 Sao Paulo, SP - Brazil

^[5] Genom Mol Engn, BR-01332000 Sao Paulo, SP - Brazil

^[6] Pasteur Inst Sao Paulo State, BR-01311000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INFECTION GENETICS AND EVOLUTION; v. 80, JUN 2020.
• Citações Web of Science: 0

Resumo

The World Health Organization (WHO), reports that rabies causes tens of thousands of deaths every year killing humans, non-human primates and other animals. Rabies continues to be a public health issue, despite the existence of effective vaccines. The dogs remain the primary reservoir and transmitter of rabies to humans globally. In the Americas, bats are regarded as the second most common source of rabies virus to humans. The vampire bat Desmodus rotundus has been identified as a natural reservoir of rabies virus (RABV) in this region. The complete genome of the RABV variant maintained by populations of vampire bats D. rotundus has rarely been reported. In this study, we sequenced and analyzed the genome of a RABV variant detected in D. rotundus. The sample, collected from an endemic area in Sao Paulo State, was phylogenetically compared with the genome of the standard sample for species Rabies virus as well as other samples belonging to terrestrial and bat-associated cycles of rabies transmission, available in GenBank. Distinct patterns linked to the genetic lineage were identified. These data can aid in the understanding of the molecular epidemiology of this virus and the epidemiological importance of this species in the transmission of the RABV. (AU)

• Processo FAPESP: 07/01843-0 - Estudo genético da variante do vírus da raiva mantida por populações de morcego hematófago Desmodus rotundus por meio do sequenciamento completo do genoma viral
• Beneficiário: Silvana Regina Favoretto
• Modalidade de apoio: Auxílio à Pesquisa - Regular