Partial remission in Brazilian children and adolescents with type 1 diabetes. Association with a haplotype of class II human leukocyte antigen and synthesis of autoantibodies

Autor(es):Mostrar menos -

Camilo, Daniela S. ^[1] ; Pradella, Fernando ^[1] ; Paulino, Maria Fernanda ^[2] ; Baracat, Emilio C. E. ^[2] ; Marini, Sofia H. ^[2] ; Guerra, Jr., Gil ^[2] ; Pavin, Elizabeth J. ^[3] ; Parisi, Candida ^[3] ; Longhini, Ana Leda F. ^[1] ; Marques, Silvia B. ^[4] ; Guariento, Edilaine G. ^[4] ; Lieber, Sofia R. ^[4] ; Macedo, Carlos Fernando ^[1] ; Gama e Silva, Leticia ^[1] ; Farias, Alessandro S. ^{[1, 5]} ; Santos, Leonilda M. B. ^{[1, 5]} ; Volpini, Walkyria M. G. ^[1]

Afiliação do(s) autor(es)

^[1] Campinas Univ UNICAMP, Inst Biol, Neuroimmunol Unit, Campinas - Brazil

^[2] Campinas Univ UNICAMP, Dept Pediat, Campinas - Brazil

^[3] Campinas Univ UNICAMP, Endocrinol Diabet Serv, Clin Hosp, Campinas - Brazil

^[4] Campinas Univ UNICAMP, Blood Ctr, HLA Lab, Campinas - Brazil

^[5] CNPq, Natl Inst Sci & Technol Neuroimmunomodulat INCT N, Brasilia, DF - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PEDIATRIC DIABETES; v. 21, n. 4, p. 606-614, JUN 2020.
• Citações Web of Science: 0

Resumo

Objective Characterization of partial remission using the insulin dose-adjusted HbA1c (IDAA1c) <= 9 definition in a multiethnic Brazilian population of children and adolescents with type 1 diabetes (T1D), in addition with the determination of both Class II HLA genotype and autoantibodies. Methods We analyzed the prevalence of partial remission in 51 new-onset T1D patients with a median time follow-up of 13 months from diagnosis. For this study, anti-GAD65, anti-IA2 and HLA class II genotyping were considered. Results Partial remission occurred in 41.2% of T1D patients until 3 months after diagnosis, mainly in those aged 5-15 years. We have demonstrated a significant increase in the haplotypes of class II HLA DRB1{*}0301-DQB1{*}0201 in children and adolescents with a partial remission phase of the disease (42.9% vs 21.7% in non-remitters, P = .0291). This haplotype was also associated with the reduction of anti-IA2 antibodies production. Homozygote DRB1{*}03-DQB1{*}0201/DRB1{*}03-DQB1{*}0201 children had the lowest prevalence of IA-2A antibodies (P = .0402). However, this association does not correlate with the time of the remission phase. Conclusion Although the number of patients studied was reduced, our data suggested that the association between genetics and decrease in antibody production to certain islet auto-antigen may contribute, at least in part, to the remission phase of T1D. (AU)

• Processo FAPESP: 12/24667-1 - Estudo funcional de imunidade celular em brasileiros com diabetes tipo 1 A em diferentes fases da doença e sua integração com marcadores humorais
• Beneficiário: Daniela Franchi Pereira da Silva Camilo
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 16/17404-5 - Estudo das subpopulações de linfócitos b no sangue periférico de pacientes com esclerose múltipla primária progressiva
• Beneficiário: Leonilda Maria Barbosa dos Santos
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/12109-7 - Estudo funcional de imunidade celular em brasileiros com diabetes tipo 1 a em diferentes fases da doença e sua integração com marcadores genéticos e humorais
• Beneficiário: Walkyria Mara Gonçalves Volpini
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/04565-0 - Estudo da função imunoreguladora da molécula HLA-G na esclerose múltipla e na encefalomielite experimental auto-imune
• Beneficiário: Leonilda Maria Barbosa dos Santos
• Modalidade de apoio: Auxílio à Pesquisa - Regular