| Texto completo | |
| Autor(es): |
Barros-Filho, Mateus C.
[1]
;
de Mello, Julia B. H.
[1]
;
Marchi, Fabio A.
[1]
;
Pinto, Clovis A. L.
[2]
;
da Silva, Igor C.
[3]
;
Damasceno, Patricia K. F.
[4]
;
Soares, Milena B. P.
[4, 5]
;
Kowalski, Luiz P.
[6]
;
Rogatto, Silvia R.
[7]
Número total de Autores: 9
|
| Afiliação do(s) autor(es): | [1] AC Camargo Canc Ctr, Int Res Ctr, CIPE, Sao Paulo - Brazil
[2] AC Camargo Canc Ctr, Dept Pathol, Sao Paulo - Brazil
[3] Sao Rafael Hosp, Dept Pathol, Salvador, BA - Brazil
[4] Fiocruz MS, Goncalo Moniz Inst, Salvador, BA - Brazil
[5] SENAI CIMATEC, Hlth Technol Inst, Salvador, BA - Brazil
[6] AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo - Brazil
[7] Univ Southern Denmark, Inst Reg Hlth Res, Dept Clin Genet, Vejle Univ Hosp, Odense - Denmark
Número total de Afiliações: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | FRONTIERS IN ENDOCRINOLOGY; v. 11, APR 30 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Currently, there is a lack of efficient recurrence prediction methods for papillary thyroid carcinoma (PTC). In this study, we enrolled 202 PTC patients submitted to total thyroidectomy and radioiodine therapy with long-term follow-up (median = 10.7 years). The patients were classified as having favorable clinical outcome (PTC-FCO, no disease in the follow-up) or recurrence (PTC-RE). Alterations in BRAF, RAS, RET, and TERT were investigated (n = 202) and the transcriptome of 48 PTC (>10 years of follow-up) samples was profiled. Although no mutation was associated with the recurrence risk, 68 genes were found as differentially expressed in PTC-RE compared to PTC-FCO. Pathway analysis highlighted a potential role of cancer-related pathways, including signal transduction and FoxO signaling. Among the eight selected genes evaluated by RT-qPCR, SLC2A4 and GADD45B showed down-expression exclusively in the PTC-FCO group compared to non-neoplastic tissues (NT). Increased expression of GADD45B was an independent marker of shorter disease-free survival {[}hazard ratio (HR) 2.9; 95% confidence interval (CI95) 1.2-7.0] in our cohort and with overall survival in the TCGA dataset (HR = 4.38, CI95 1.2-15.5). In conclusion, GADD45B transcript was identified as a novel prognostic marker candidate in PTC patients treated with total thyroidectomy and radioiodine therapy. (AU) | |
| Processo FAPESP: | 15/20748-5 - MARCADORES DIAGNÓSTICOS E PROGNÓSTICOS APLICÁVEIS NA PRÁTICA CLINICA PARA PACIENTES COM NÓDULOS TIREOIDIANOS: validação de achados prévios e estudos funcionais |
| Beneficiário: | Silvia Regina Rogatto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 15/17707-5 - Desenvolvimento de métodos moleculares úteis para o diagnóstico diferencial de nódulos da tireoide |
| Beneficiário: | Mateus de Camargo Barros Filho |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |