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GADD45B Transcript Is a Prognostic Marker in Papillary Thyroid Carcinoma Patients Treated With Total Thyroidectomy and Radioiodine Therapy

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Autor(es):
Barros-Filho, Mateus C. [1] ; de Mello, Julia B. H. [1] ; Marchi, Fabio A. [1] ; Pinto, Clovis A. L. [2] ; da Silva, Igor C. [3] ; Damasceno, Patricia K. F. [4] ; Soares, Milena B. P. [4, 5] ; Kowalski, Luiz P. [6] ; Rogatto, Silvia R. [7]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] AC Camargo Canc Ctr, Int Res Ctr, CIPE, Sao Paulo - Brazil
[2] AC Camargo Canc Ctr, Dept Pathol, Sao Paulo - Brazil
[3] Sao Rafael Hosp, Dept Pathol, Salvador, BA - Brazil
[4] Fiocruz MS, Goncalo Moniz Inst, Salvador, BA - Brazil
[5] SENAI CIMATEC, Hlth Technol Inst, Salvador, BA - Brazil
[6] AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo - Brazil
[7] Univ Southern Denmark, Inst Reg Hlth Res, Dept Clin Genet, Vejle Univ Hosp, Odense - Denmark
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: FRONTIERS IN ENDOCRINOLOGY; v. 11, APR 30 2020.
Citações Web of Science: 0
Resumo

Currently, there is a lack of efficient recurrence prediction methods for papillary thyroid carcinoma (PTC). In this study, we enrolled 202 PTC patients submitted to total thyroidectomy and radioiodine therapy with long-term follow-up (median = 10.7 years). The patients were classified as having favorable clinical outcome (PTC-FCO, no disease in the follow-up) or recurrence (PTC-RE). Alterations in BRAF, RAS, RET, and TERT were investigated (n = 202) and the transcriptome of 48 PTC (>10 years of follow-up) samples was profiled. Although no mutation was associated with the recurrence risk, 68 genes were found as differentially expressed in PTC-RE compared to PTC-FCO. Pathway analysis highlighted a potential role of cancer-related pathways, including signal transduction and FoxO signaling. Among the eight selected genes evaluated by RT-qPCR, SLC2A4 and GADD45B showed down-expression exclusively in the PTC-FCO group compared to non-neoplastic tissues (NT). Increased expression of GADD45B was an independent marker of shorter disease-free survival {[}hazard ratio (HR) 2.9; 95% confidence interval (CI95) 1.2-7.0] in our cohort and with overall survival in the TCGA dataset (HR = 4.38, CI95 1.2-15.5). In conclusion, GADD45B transcript was identified as a novel prognostic marker candidate in PTC patients treated with total thyroidectomy and radioiodine therapy. (AU)

Processo FAPESP: 15/20748-5 - Marcadores diagnósticos e prognósticos aplicáveis na prática clínica para pacientes com nódulos tireoidianos: validação de achados prévios e estudos funcionais
Beneficiário:Silvia Regina Rogatto
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/17707-5 - Desenvolvimento de métodos moleculares úteis para o diagnóstico diferencial de nódulos da tireóide
Beneficiário:Mateus de Camargo Barros Filho
Linha de fomento: Bolsas no Brasil - Pós-Doutorado