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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Moderate intake of BCAA-rich protein improves glucose homeostasis in high-fat-fed mice

Texto completo
Autor(es):
Roquetto, Aline Rissetti [1] ; Moura, Carolina Soares [1] ; Santos-Junior, Valfredo de Almeida [1] ; Sammarco Oliveira, Paulo Otavio [1] ; Aires Machado, Karla Idelca [1] ; Borges Castro Carvalho, Gessika Cristina [1] ; Risso, Eder Muller [1] ; Amaya-Farfan, Jaime [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Campinas UNICAMP, Food & Nutr Program, Sch Food Engn, Campinas, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF NUTRITIONAL BIOCHEMISTRY; v. 80, JUN 2020.
Citações Web of Science: 0
Resumo

Notwithstanding the fact that dietary branched-chain amino acids (BCAAs) have been considered to be a cause of insulin resistance (IR), evidence indicates that BCAA-rich whey proteins (WPs) do not lead to IR in animals consuming high-fat (HF) diets and may instead improve glucose homeostasis. To address the role of BCAA-rich WP as dietary protein in IR and inflammatory response, we fed C57BLJ6J mice either high-fat (HF) or low-fat (LF) diets formulated with moderate protein levels (13% w/w) of either WP or hydrolyzed WP (WPH) and compared them with casein (CAS) as a reference. The muscle and plasma free amino acid profiles, inflammatory parameters and glycemic homeostasis were examined. While the LF/CAS diet promoted the rise in triglycerides and inflammatory parameters, the HF/CAS induced typical IR responses and impaired biochemical parameters. No differences in plasma BCAAs were detected, but the HF/WPH diet led to a twofold increase in gastrocnemius muscle free amino acids, including BCAAs. In general, ingestion of WPH was effective at averting or attenuating the damage caused by both the LF and HFdiets. No high concentrations of BCAAs in the plasma or signs of IR were found in those mice fed an HF diet along with the hydrolyzed whey proteins. It is concluded that consumption of BCAA-rich whey proteins, especially WPH, does not result in the development of IR. (C) 2020 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 17/16886-9 - Impacto do consumo das proteínas do soro do leite na expressão das heat-shock proteins (HSPs) e na microbiota intestinal
Beneficiário:Jaime Amaya Farfan
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/06630-4 - Efeito do consumo das proteínas do soro do leite sobre as heat shock proteins (HSPs) em animais obesos induzidos por dieta cafeteria
Beneficiário:Carolina Soares de Moura
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 09/51580-1 - Efeito da polimerizacao por transglutaminase e da proteolise na estrutura e antigenicidade da beta-lactoglobulina
Beneficiário:Flavia Maria Netto
Linha de fomento: Auxílio à Pesquisa - Regular