Cascate reactions of progesterone by mycelia and culture broth from marine-derived fungus Aspergillus sydowii CBMAI 935

Autor(es)

Cardoso de Paula, Samuel Filipe ^[1] ; Meleiro Porto, Andre Luiz ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Lab Quim Organ & Biocatalise, Inst Quim Sao Carlos, Ave Joao Dagnone 1100, Ed Quim Ambiental, BR-13563120 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY; v. 25, MAY 2020.
• Citações Web of Science: 0

Resumo

In this work, bio-oxidation cascate reactions of steroid progesterone were performed using culture broth and mycelia from marine-derived fungus Aspergillus sydowii CBMAI 935. The major products obtained from progesterone by Baeyer-Villiger cascate reactions were testosterone and testololactone. The bio-oxydation reactions were performed in quintuplicate experiments (32 degrees C, 130 rpm, pH 7.4); after seven days in presence of culture broth, testosterone and testololactone were isolated in 24% and 36% yield, respectively. The testololactone was also isolated from mycelia after seven days in 87% yield. This study involving the cascate reaction of progesterone demonstrated the microbial biotransformation potential for steroidal drugs in environment by marine-derived fungi. (AU)

• Processo FAPESP: 16/20155-7 - Reações de aminólise e de resolução cinética por lipases e biodegradação de agroquímicos por microrganismos
• Beneficiário: Andre Luiz Meleiro Porto
• Modalidade de apoio: Auxílio à Pesquisa - Regular