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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Variants inHSD11B1gene modulate susceptibility to diabetes kidney disease and to insulin resistance in type 1 diabetes

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Autor(es):
Mori, Rosana Cristina [1] ; Santos-Bezerra, Daniele Pereira [2] ; Pelaes, Tatiana Souza [2] ; Admoni, Sharon Nina [2] ; Perez, Ricardo Vessoni [2] ; Monteiro, Maria Beatriz [2] ; Machado, Cleide Guimaraes [3] ; Queiroz, Marcia Silva [4] ; Machado, Ubiratan Fabres [1, 5] ; Correa-Giannella, Maria Lucia [6, 2]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Ave Prof Lineu Prestes 1524, BR-05508900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Hosp Clin HCFMUSP, Lab Carboidratos & Radioimunoensaios LIM 18, Fac Med, Sao Paulo - Brazil
[3] Univ Sao Paulo, Hosp Clin HCFMUSP, Div Oftalmol, Fac Med, Sao Paulo - Brazil
[4] Univ Sao Paulo, Hosp Clin HCFMUSP, Div Endocrinol, Fac Med, Sao Paulo - Brazil
[5] Correa-Giannella, Maria Lucia, Univ Nove Julho UNINOVE, Programa Posgrad Med, Sao Paulo, Brazil.Mori, Rosana Cristina, Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Ave Prof Lineu Prestes 1524, BR-05508900 Sao Paulo - Brazil
[6] Univ Nove Julho Uninove, Programa Posgrad Med, Sao Paulo - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: DIABETES-METABOLISM RESEARCH AND REVIEWS; v. 37, n. 1 JUN 2020.
Citações Web of Science: 0
Resumo

Background and aim 11 beta-Hydroxysteroid dehydrogenase 1 has been implicated in insulin resistance (IR) in the setting of metabolic disorders, and single nucleotide polymorphisms (SNPs) in its encoding gene (HSD11B1) have been associated with type 2 diabetes and metabolic syndrome. In type 1 diabetes (T1D), IR has been related to the development of chronic complications. We investigated the association ofHSD11B1SNPs with microvascular complications and with IR in a Brazilian cohort of T1D individuals. Materials and methods Five SNPs were genotyped in 466 T1D individuals (57% women; median of 37 years old, diabetes duration of 25 years and HbA1c of 8.4%). Results The minor allele T of rs11799643 was nominally associated with diabetic retinopathy (OR = 0.52; confidence interval {[}CI] 95% = 0.28-0.96;P= .036). The minor allele C of rs17389016 was nominally associated with overt diabetic kidney disease (DKD) (OR = 1.90; CI 95% = 1.07-3.37;P= .028). A follow-up study revealed that 29% of the individuals lost >= 5 mL min(-1)x 1.73 m(2)per year of the estimated glomerular filtration rate (eGFR). In these individuals (eGFR decliners), C allele of rs17389016 was more frequent than in non-decliners (OR = 2.10; CI 95% = 1.14-3.89;P= .018). Finally, minor allele T of rs846906 associated with higher prevalence of arterial hypertension, higher body mass index and waist circumference, thus conferring risk to a lower estimated glucose disposal rate, a surrogate marker of insulin sensitivity (OR = 1.23; CI 95% = 1.06-1.42;P= .004). Conclusion SNPs in theHSD11B1gene may confer susceptibility to DKD and to IR in T1D individuals. (AU)

Processo FAPESP: 16/15603-0 - Desvendando mecanismos envolvidos no controle glicêmico e nas complicações crônicas do Diabetes mellitus: contribuições à saúde humana
Beneficiário:Ubiratan Fabres Machado
Linha de fomento: Auxílio à Pesquisa - Temático