| Texto completo | |
| Autor(es): Mostrar menos - |
Steenwyk, Jacob L.
[1]
;
Lind, Abigail L.
[2, 3]
;
Ries, Laure N. A.
[4, 5]
;
dos Reis, Thaila F.
[4, 5]
;
Silva, Lilian P.
[5]
;
Almeida, Fausto
[4]
;
Bastos, Rafael W.
[5]
;
Fraga da Silva, Thais Fernanda de Campos
[4]
;
Bonato, Vania L. D.
[4]
;
Pessoni, Andre Moreira
[4]
;
Rodrigues, Fernando
[6, 7]
;
Raja, Huzefa A.
[8]
;
Knowles, Sonja L.
[8]
;
Oberlies, Nicholas H.
[8]
;
Lagrou, Katrien
[9, 10, 11]
;
Goldman, Gustavo H.
[5]
;
Rokas, Antonis
[1, 2]
Número total de Autores: 17
|
| Afiliação do(s) autor(es): Mostrar menos - | [1] Vanderbilt Univ, Dept Biol Sci, 465 21st Ave South, Nashville, TN 37235 - USA
[2] Vanderbilt Univ, Dept Biomed Informat, Sch Med, 1211 Med Ctr Dr, Nashville, TN 37232 - USA
[3] Gladstone Inst Data Sci & Biotechnol, San Francisco, CA 94158 - USA
[4] Univ Sao Paulo FMRP USP, Dept Bioquim & Imunol, Vila Monte Alegre, Fac Med Ribeirao Preto, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[5] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Crencias Farmaceut, Ave Caf S-N, BR-14040903 Ribeirao Preto - Brazil
[6] Univ Minho, Sch Med, Life & Hlth Sci Res Inst ICVS, P-4715495 Braga - Portugal
[7] ICVS 3Bs PT Govt Associate Lab, P-4715495 Braga - Portugal
[8] Univ N Carolina, Dept Chem & Biochem, 1400 Spring Garden St, Greensboro, NC 27412 - USA
[9] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, B-3000 Leuven - Belgium
[10] Univ Hosp Leuven, Dept Lab Med, B-3000 Leuven - Belgium
[11] Univ Hosp Leuven, Natl Reference Ctr Mycosis, B-3000 Leuven - Belgium
Número total de Afiliações: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Current Biology; v. 30, n. 13, p. 2495+, JUL 6 2020. |
| Citações Web of Science: | 3 |
| Resumo | |
Interspecific hybridization substantially alters genotypes and phenotypes and can give rise to new lineages. Hybrid isolates that differ from their parental species in infection-relevant traits have been observed in several human-pathogenic yeasts and plant-pathogenic filamentous fungi but have yet to be found in human-pathogenic filamentous fungi. We discovered 6 clinical isolates from patients with aspergillosis originally identified as Aspergillus nidulans (section Nidulantes) that are actually allodiploid hybrids formed by the fusion of Aspergillus spinulosporus with an unknown close relative of Aspergillus quadrilineatus, both in section Nidulantes. Evolutionary genomic analyses revealed that these isolates belong to Aspergillus latus, an allodiploid hybrid species. Characterization of diverse infection-relevant traits further showed that A. latus hybrid isolates are genomically and phenotypically heterogeneous but also differ from A. nidulans, A. spinulosporus, and A. quadrilineatus. These results suggest that allodiploid hybridization contributes to the genomic and phenotypic diversity of filamentous fungal pathogens of humans. (AU) | |
| Processo FAPESP: | 17/14159-2 - O papel do metabolismo da lactose e do acetato na virulência de Aspergillus fumigatus |
| Beneficiário: | Laure Nicolas Annick Ries |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 16/03322-7 - Papel de galectina-3 na infecção por Cryptococcus neoformans |
| Beneficiário: | Fausto Bruno dos Reis Almeida |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 16/07870-9 - A influência de proteínas quinases ativadas por mitógenos (MAPK) na expressão de determinantes genéticos importantes para a virulência de Aspergillus fumigatus |
| Beneficiário: | Gustavo Henrique Goldman |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |