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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Surface properties of calcium aluminate cement blends for bone repair applications

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Autor(es):
Oliveira, I. R. [1] ; Barbosa, A. M. [1] ; Grancianinov, K. J. S. [1] ; Origo, F. D. [2] ; dos Santos, K. W. [1] ; Leite, P. M. S. C. M. [1] ; Raniero, L. J. [1] ; Pandolfelli, V. C. [3]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Vale Paraiba, Inst Res & Dev, Av Shishima Hifumi 2911, Sao Jose Dos Campos, SP - Brazil
[2] Inst Adv Studies IEAV CTA, Sao Jose Dos Campos, SP - Brazil
[3] Fed Univ Sao Carlos UFSCar, Mat Engn Dept, Rod Washington Luiz, Km 235, Sao Carlos, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: CERAMICS INTERNATIONAL; v. 46, n. 9, p. 14241-14251, JUN 15 2020.
Citações Web of Science: 1
Resumo

Surface composition and its roughness affect the interactions that induce bone tissue growth in a biomaterial. Irregular surfaces result in better bone fixation than smoother ones, indicating that this feature might have a direct influence on osteoblast adhesion. In this paper, some surface properties of calcium aluminate cement (CAC)-based blends were evaluated, compared to commercial products as mineral trioxide aggregate (MTA) and polimetylmethacrylate (PMMA) as a reference. Roughness was measured by profilometry using samples without or with SBF (simulated body fluid) treatment for 21 days. The collagen samples, MTA and PMMA, presented higher roughness values before SBF treatment. After SBF exposure, all samples except those with PMMA showed an increase in roughness, especially the MTA ones. Cell adhesion was observed by SEM after contact with mesenchymal cell cultures. The latter adhered to the sample's surface pointing out their biocompatibility. Finally, the interactions of samples with culture medium (Dulbecco's Modified Eagle Medium = DMEM) were measured for periods of 1, 3, 7, 14, and 21 days. The sample surfaces were evaluated by SEM, EDX, FTIR and XRD. After the contact of samples with culture medium, the calcium concentration was measured by atomic absorption spectroscopy. All CAC-based blends and mainly MTA presented precipitation after treatment with DMEM, which was characterized as calcium phosphate and mainly calcium carbonate. (AU)

Processo FAPESP: 16/15032-3 - Caracterização in vitro e in vivo de blendas a base de cimento aluminoso visando aplicação no reparo e regeneração do tecido ósseo
Beneficiário:Ivone Regina de Oliveira
Linha de fomento: Auxílio à Pesquisa - Regular