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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Papez Circuit Gray Matter and Episodic Memory in Amyotrophic Lateral Sclerosis and Behavioural Variant Frontotemporal Dementia

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Autor(es):
Arantes Bueno, Ana Paula [1] ; de Souza, Leonardo Cruz [2, 3] ; Lopez Pinaya, Walter Hugo [4, 1] ; Teixeira, Antonio Lucio [5, 6] ; Rousseff de Prado, Laura Godoy [3] ; Caramelli, Paulo [2, 3] ; Hornberger, Michael [7, 8] ; Sato, Joao Ricardo [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Fed ABC, Ctr Math Comp & Cognit, Santo Andre, SP - Brazil
[2] Univ Fed Minas Gerais, Fac Med, Dept Internal Med, Belo Horizonte, MG - Brazil
[3] Univ Fed Minas Gerais, Programa Posgrad Neurociencias, Belo Horizonte, MG - Brazil
[4] Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London - England
[5] Univ Texas Hlth, Dept Psychiat & Behav Sci, Houston, TX - USA
[6] Santa Casa BH Ensino & Pesquisa, Belo Horizonte, MG - Brazil
[7] Univ East Anglia, Norwich Med Sch, Dept Med, Norwich, Norfolk - England
[8] Norfolk & Suffolk NHS Fdn Trust, Norwich, Norfolk - England
Número total de Afiliações: 8
Tipo de documento: Artigo Científico
Fonte: BRAIN IMAGING AND BEHAVIOR; JUL 2020.
Citações Web of Science: 1
Resumo

Amyotrophic lateral sclerosis and behavioural variant frontotemporal dementia are two different diseases recognized to overlap at clinical, pathological and genetic characteristics. Both conditions are traditionally known for relative sparing of episodic memory. However, recent studies have disputed that with the report of patients presenting with marked episodic memory impairment. Besides that, structural and functional changes in temporal lobe regions responsible for episodic memory processing are often detected in neuroimaging studies of both conditions. In this study, we investigated the gray matter features associated with the Papez circuit in amyotrophic lateral sclerosis, behavioural variant frontotemporal dementia and healthy controls to further explore similarities and differences between the two conditions. Our non-demented amyotrophic lateral sclerosis patients showed no episodic memory deficits measured by a short-term delayed recall test while no changes in gray matter of the Papez circuit were found. Compared with the amyotrophic lateral sclerosis group, the behavioural variant frontotemporal dementia group had lower performance on the short-term delayed recall test and marked atrophy in gray matter of the Papez circuit. Bilateral atrophy of entorhinal cortex and mammillary bodies distinguished behavioural variant frontotemporal dementia from amyotrophic lateral sclerosis patients as well as atrophy in left cingulate, left hippocampus and right parahippocampal gyrus. Taken together, our results suggest that sub-regions of the Papez circuit could be differently affected in amyotrophic lateral sclerosis and behavioural variant frontotemporal dementia. (AU)

Processo FAPESP: 16/19376-9 - Integridade estrutural e funcional do circuito de Papez e sua relação com a simtomatologia na Esclerose Lateral Amiotrófica
Beneficiário:Ana Paula Arantes de Andrade Bueno
Linha de fomento: Bolsas no Brasil - Doutorado