Bilayer Mucoadhesive Buccal Film for Mucosal Ulcers Treatment: Development, Characterization, and Single Study Case

Autor(es)

Alves, Thais F. R. ^[1] ; Rios, Alesssandra C. ^[1] ; Pontes, Katiusca da Silva ^[1] ; Portella, Decio L. ^{[1, 2]} ; Aranha, Norberto ^[1] ; Severino, Patricia ^{[3, 4]} ; Souto, Eliana B. ^{[5, 6]} ; Gonsalves, Joyce K. M. ^[7] ; Nunes, Rogeria de Souza ^[7] ; Chaud, V, Marco

Afiliação do(s) autor(es)

^[1] V, Univ Sorocaba, Lab Biomat & Nanotechnol LaBNUS, BR-18023000 Sorocaba, SP - Brazil

^[2] Pontifical Catholic Univ, Sch Med, Dept Surg Plast, BR-18030070 Sorocaba, SP - Brazil

^[3] Univ Tiradentes Unit, Biotechnol Postgrad Program, BR-49010390 Aracaju, Sergipe - Brazil

^[4] Inst Technol & Res ITP, Nanomed & Nanotechnol Lab LNMed, BR-49010390 Aracaju, Sergipe - Brazil

^[5] Univ Minho, Ctr Biol Engn CEB, P-4710057 Braga - Portugal

^[6] Univ Coimbra, Fac Pharm, P-3000548 Coimbra - Portugal

^[7] Univ Fed Sergipe, Dept Pharm, BR-49100000 St Christopher, Sergipe - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PHARMACEUTICS; v. 12, n. 7 JUL 2020.
• Citações Web of Science: 0

Resumo

The formation of mucosal ulcers is an end result of epithelial damage, and it occurs due to some specific causes, such as trauma, aphthous stomatitis, lichen planus and lichenoid reactions, cytotoxic effects of chemotherapy and radiation, and drug-induced hypersensitivity reactions and malignant settings. This study focused on films for target drug delivery with respect to the treatment of the diseases of the oral mucosa, specifically mucositis. The results of a single clinical study as a pre-experimental design was performed and followed up to the outcome until 30 days. The polymeric film was prepared in a mucoadhesive bilayer structure: the basal layer with lidocaine HCl had a faster release than the apical layer with benzydamine HCl andN-acetyl-cysteine. Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), and SEM characterized the physical-chemical and morphological properties. The cell viability and cytotoxicity were evaluated in cell line MCF7. The transport mechanism of the solvent (swelling) and the drugs in the basal or apical layer (drug release) was explained with mathematical models. To evaluate the effect of movement inside the mouth, the folding endurance was determined. The mucoadhesive bilayer film is biologically safe and stimulates cellular proliferation. A single study in vivo demonstrated the therapeutic effect of the mucoadhesive bilayer film in buccal mucositis. (AU)

• Processo FAPESP: 11/21219-5 - Preparação, caracterização in vitro e avaliação in vivo de filmes poliméricos mucoadesivos para prevenção e tratamento da mucosite oral aguda induzida por quimioterapia e radioterapia
• Beneficiário: Marco Vinícius Chaud
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/13432-0 - Desenvolvimento de scaffolds para aplicações odontológicas
• Beneficiário: Norberto Aranha
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/11350-6 - Extração e caracterização do ULVAN: uma plataforma para preparação de sistemas biomiméticos particulados para permeação intestinal de ácido hialurônico e sulfato de condroitina de origem vegetal (Ulva lactuca)
• Beneficiário: Kessi Marie de Moura Crescencio
• Modalidade de apoio: Bolsas no Brasil - Mestrado