Naturally Acquired Humoral Immunity against Malaria Parasites in Non-Human Primates from the Brazilian Amazon, Cerrado and Atlantic Forest

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Monteiro, Eliana Ferreira ^[1] ; Fernandez-Becerra, Carmen ^{[2, 3]} ; Araujo, Maisa da Silva ^[4] ; Messias, Mariluce Rezende ^[5] ; Ozaki, Luiz Shozo ^[6] ; Ribeiro de Castro Duarte, Ana Maria ^{[1, 7]} ; Bueno, Marina Galvao ^[8] ; Catao-Dias, Jose Luiz ^[9] ; Fernandes Chagas, Carolina Romeiro ^{[10, 11]} ; Mathias, Bruno da Silva ^[1] ; dos Santos, Mayra Gomes ^[12] ; Santos, Stefanie Vanessa ^{[12, 13]} ; Holcman, Marcia Moreira ^[7] ; de Souza Jr, Julio Cesar ; Kirchgatter, Karin ^{[1, 7]}

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^[1] Univ Sao Paulo, Fac Med, Inst Med Trop, BR-05403000 Sao Paulo, SP - Brazil

^[2] Hosp Clin Univ Barcelona, ISGlobal, Barcelona 08036 - Spain

^[3] Germans Trias i Pujol Hlth Sci Res Inst IGTP, Badalona 08916 - Spain

^[4] Fundacao Oswaldo Cruz, Fiocruz Rondonia, Inst Oswaldo Cruz, BR-76812245 Porto Velho, RO - Brazil

^[5] Univ Fed Rondonia, Dept Biol, BR-78900000 Porto Velho, RO - Brazil

^[6] Virginia Commonwealth Univ, Life Sci, Med Coll Virginia Campus, Richmond, VA 23284 - USA

^[7] Superintendencia Controle Endemias Estado Sao Paul, Dept Labs Especializados, BR-01027000 Sao Paulo, SP - Brazil

^[8] Fundacao Oswaldo Cruz, Fiocruz Rio de Janeiro, Inst Oswaldo Cruz, BR-21040900 Rio De Janeiro, RJ - Brazil

^[9] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Patol, BR-05508270 Sao Paulo, SP - Brazil

^[10] Fundacao Parque Zool Sao Paulo, Dept Pesquisas Aplicadas, BR-04301905 Sao Paulo, SP - Brazil

^[11] Nat Res Ctr, Inst Ecol, LT-08412 Vilnius - Lithuania

^[12] Univ Cruzeiro Sul, Dept Patol, BR-01311925 Sao Paulo, SP - Brazil

^[13] AC Camargo Canc Ctr, Dept Anat Patol, BR-01525001 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PATHOGENS; v. 9, n. 7 JUL 2020.
• Citações Web of Science: 0

Resumo

Non-human primates (NHPs) have been shown to be infected by parasites of the genusPlasmodium, the etiological agent of malaria in humans, creating potential risks of zoonotic transmission.Plasmodium brasilianum, a parasite species similar toP. malariaeof humans, have been described in NHPs from Central and South America, including Brazil. The merozoite surface protein 1 (MSP1), besides being a malaria vaccine candidate, is highly immunogenic. Due to such properties, we tested this protein for the diagnosis of parasite infection. We used recombinant proteins ofP. malariaeMSP1, as well as ofP. falciparumandP. vivax, for the detection of antibodies anti-MSP1 of these parasite species, in the sera of NHPs collected in different regions of Brazil. About 40% of the NHP sera were confirmed as reactive to the proteins of one or more parasite species. A relatively higher number of reactive sera was found in animals from the Atlantic Forest than those from the Amazon region, possibly reflecting the former more intense parasite circulation among NHPs due to their proximity to humans at a higher populational density. The presence ofPlasmodiumpositive NHPs in the surveyed areas, being therefore potential parasite reservoirs, needs to be considered in any malaria surveillance program. (AU)

• Processo FAPESP: 14/10919-4 - Aspectos epidemiológicos da malária humana e símia em áreas de Mata Atlântica no entorno da cidade de São Paulo: estudo da fauna de anofelinos e infecção natural por Plasmodium sp. em Parelheiros e na Serra da Cantareira
• Beneficiário: Ana Maria Ribeiro de Castro Duarte
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/04559-0 - Análise do relacionamento filogeográfico e imunológico de Plasmodium malariae e Plasmodium brasilianum
• Beneficiário: Karin Kirchgatter Hildebrand
• Linha de fomento: Auxílio à Pesquisa - Regular