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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Obesity/Metabolic Syndrome and Diabetes Mellitus on Peri-implantitis

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Autor(es):
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de Oliveira, Paula Gabriela Faciola Pessoa [1, 2, 3] ; Bonfante, Estevam A. [4] ; Bergamo, Edmara T. P. [4] ; de Souza, Sergio Luis Scombatti [2] ; Riella, Leonardo [5] ; Torroni, Andrea [6] ; Jalkh, Ernesto B. Benalcazar [4, 1] ; Witek, Lukasz [1, 7] ; Lopez, Christopher D. [8] ; Zambuzzi, Willian Fernando [9] ; Coelho, Paulo G. [1, 6, 10]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] NYU, Coll Dent, Dept Biomat & Biomimet, New York, NY 10010 - USA
[2] Univ Sao Paulo, Dept Oral & Maxillofacial Surg & Periodont, Sch Dent Ribeirao Preto, Ribeirao Preto, SP - Brazil
[3] Univ Ctr State Para, Sch Dent, Dept Periodontol, Belem, PA - Brazil
[4] Univ Sao Paulo, Bauru Sch Dent, Dept Prosthodont & Periodontol, Bauru, SP - Brazil
[5] Harvard Med Sch, Massachusetts Gen Hosp, Div Nephrol, Boston, MA 02115 - USA
[6] NYU, Hansjorg Wyss Dept Plast Surg, Langone Hlth Sch Med, New York, NY - USA
[7] NYU, Dept Biomed Engn, Tandon Sch Engn, Brooklyn, NY - USA
[8] Johns Hopkins Sch Med Baltimore, Dept Plast & Reconstruct Surg, Baltimore, MD - USA
[9] UNESP Sao Paulo State Univ, Dept Chem & Biol Sci, Bioscience Inst IBB, Botucatu, SP - Brazil
[10] NYU, Dept Mech & Aerosp Engn, Tandon Sch Engn, Brooklyn, NY - USA
Número total de Afiliações: 10
Tipo de documento: Artigo de Revisão
Fonte: TRENDS IN ENDOCRINOLOGY AND METABOLISM; v. 31, n. 8, p. 596-610, AUG 2020.
Citações Web of Science: 0
Resumo

Literature has reported that up to 50% of dental implants may be affected by peri-implantitis, a bacteria-induced chronic inflammatory process, which promotes osteoclast-mediated bone resorption and inhibits bone formation, leading to progressive bone loss around implants. Current evidence points toward an increased risk for the development of peri-implantitis in both obesity/metabolic syndrome (MetS) and diabetes mellitus (DM) conditions relative to the healthy population. Currently, there is no effective treatment for peri-implantitis and the 50% prevalence in MetS and DM, along with its predicted increase in the worldwide population, presents a major concern in implant dentistry as hyperglycemic conditions are associated with bone-healing impairment; this may be through dysfunction of osteocalcin-induced glucose metabolism. The MetS/DM proinflammatory systemic condition and altered immune/microbiome response affect both catabolic and anabolic events of bone-healing that include increased osteoclastogenesis and compromised osteoblast activity, which could be explained by the dysfunction of insulin receptor that led to activation of signals related with osteoblast differentiation. Furthermore, chronic hyperglycemia along with associated micro- and macro-vascular ailments leads to delayed/impaired wound healing due to activation of pathways that are particularly important in initiating events linked to inflammation, oxidative stress, and cell apoptosis; this may be through deactivation of AKT/PKB protein, which possesses a pivotal role in drive survival and eNOS signaling. This review presents an overview of the local and systemic mechanisms synergistically affecting bone-healing impairment in MetS/DM individuals, as well as a rationale for hierarchical animal model selection, in an effort to characterize peri-implantitis disease and treatment. (AU)

Processo FAPESP: 12/19078-7 - Desenvolvimento e processamento de compósito de Al2O3-ZrO2 para próteses monolíticas CAD/CAM: efeito do envelhecimento na resistência à flexão biaxial
Beneficiário:Estevam Augusto Bonfante
Linha de fomento: Auxílio à Pesquisa - Jovens Pesquisadores
Processo FAPESP: 18/03072-6 - Compósitos experimentais 70%Al2O3-30%ZrO2: caracterização estrutural e da sobrevida antes e após envelhecimento
Beneficiário:Ernesto Byron Benalcazar Jalkh
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 19/08693-1 - Compósitos experimentais à base de alumina e zircônia infiltrados por vidro: caracterização microestrutural e das propriedades ópticas e mecânicas.
Beneficiário:Edmara Tatiely Pedroso Bergamo
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 19/00452-5 - COMPÓSITOS EXPERIMENTAIS 70%Al2O3-30%ZrO2: CARACTERIZAÇÃO MECÂNICA, ESTRUTURAL E TOPOGRÁFICA
Beneficiário:Ernesto Byron Benalcazar Jalkh
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
Processo FAPESP: 16/18818-8 - EMU concedido no processo 2012/19078-7: ElectroPuls E3000 Linear-Torsion All-Electric dynamic test instrument package
Beneficiário:Estevam Augusto Bonfante
Linha de fomento: Auxílio à Pesquisa - Programa Equipamentos Multiusuários