Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Monocyte and Macrophage-Mediated Pathology and Protective Immunity During Schistosomiasis

Texto completo
Autor(es):
Souza, Camila Oliveira Silva [1] ; Gardinassi, Luiz Gustavo [2] ; Rodrigues, Vanderlei [3] ; Faccioli, Lucia Helena [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Anal Clin Toxicol & Bromatol, Fac Ciencias Farmaceut Ribeirao Preto, Sao Paulo - Brazil
[2] Univ Fed Goias, Dept Biociencias & Tecnol, Inst Patol Trop & Saude Publ, Goiania, Go - Brazil
[3] Univ Sao Paulo, Dept Bioquim & Imunol, Fac Med Ribeirao Preto, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo de Revisão
Fonte: FRONTIERS IN MICROBIOLOGY; v. 11, AUG 12 2020.
Citações Web of Science: 0
Resumo

Infection bySchistosomaparasites culminates in a chronic granulomatous disease characterized by intense tissue fibrosis. Along the course of schistosomiasis, diverse leukocytes are recruited for inflammatory foci. Innate immune cell accumulation in Th2-driven granulomas aroundSchistosomaeggs is associated with increased collagen deposition, while monocytes and macrophages exert critical roles during this process. Monocytes are recruited to damaged tissues from blood, produce TGF-beta and differentiate into monocyte-derived macrophages (MDMs), which become alternatively activated by IL-4/IL-13 signaling via IL-4R alpha (AAMs). AAMs are key players of tissue repair and wound healing in response toSchistosomainfection. Alternative activation of macrophages is characterized by the activation of STAT6 that coordinates the transcription ofArg1, Chi3l3, Relma, andMrc1.In addition to these markers, monocyte-derived AAMs also expressRaldh2andPdl2.AAMs produce high levels of IL-10 and TGF-beta that minimizes tissue damage caused bySchistosomaegg accumulation in tissues. In this review, we provide support to previous findings about the host response toSchistosomainfection reusing public transcriptome data. Importantly, we discuss the role of monocytes and macrophages with emphasis on the mechanisms of alternative macrophage activation during schistosomiasis. (AU)

Processo FAPESP: 14/07125-6 - Novos aspectos funcionais dos eicosanóides
Beneficiário:Lúcia Helena Faccioli
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 18/22667-0 - Papel do CD18 para geração e plasticidade de monócitos durante a infecção por Schistossoma mansoni
Beneficiário:Camila de Oliveira Silva e Souza
Linha de fomento: Bolsas no Brasil - Doutorado