Malheiros, Jackeline M.
Andreeta, Mariane B.
Polli, Roberson S.
Paiva, Fernando F.
Número total de Autores: 7
Afiliação do(s) autor(es):
 Univ Fed Sao Paulo, Dept Fisiol, Sao Paulo - Brazil
 Univ Sao Paulo, Inst Fis Sao Carlos, Sao Carlos - Brazil
 Univ Fed Sao Paulo, Inst Ciencia & Tecnol, Sao Jose Dos Campos - Brazil
 Univ Sao Paulo, Inst Fis Sao Carlos, Ctr Imagens & Espectroscopia Vivo Ressonancia Mag, Sao Carlos - Brazil
 Univ Fed Sao Paulo, Dept Pediat, Disciplina Pediat Neonatal, Sao Paulo - Brazil
Número total de Afiliações: 5
Tipo de documento:
European Journal of Neuroscience;
Citações Web of Science:
Although it is known that nociceptive stimulation in the first postnatal week in rats is useful to model preterm pain, resulting in activation of specific brain areas, as assessed in vivo using manganese-enhanced magnetic resonance imaging (MEMRI), little is known about its long-term effects and sex specificity. Here we aimed to investigate whether inflammatory pain induced in male and female adult rats modify the pattern of brain activation between animals subjected or not to neonatal pain. For this, Complete Freund's adjuvant (CFA) was injected into the left hind paw of rat pups on postnatal day 1 (P1) or P8 to induce inflammatory response. During adulthood, CFA-treated and control animals were injected with CFA 1 hr prior MRI. MEMRI has the ability to enhance the contrast of selective brain structures in response to a specific stimulus, as the pain. MEMRI responses were consistent with activation of nociceptive pathways and these responses were reduced in animals treated with CFA on P1, but increased in animals treated on P8, mainly in the female group. In agreement, P8 female group showed exacerbated responses in the thermal nociceptive test. Using MEMRI, we conclude that the natural ability of adult rats to recognize and react to pain exposition is modified by neonatal painful exposition, mainly among females. (AU)