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(Referência obtida automaticamente do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Tissue reaction and anti-biofilm action of new biomaterial composed of latex from Hancornia speciosa Gomes and silver nanoparticles

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Autor(es):
JÉSSICA M. BONETE ; GUILHERME D. SILVA ; ÉDER J. GUIDELLI ; PABLO J. GONÇALVES ; LUCIANE M. ALMEIDA ; OSWALDO BAFFA ; ANGELA KINOSHITA
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: Anais da Academia Brasileira de Ciências; v. 92, n. 4, p. -, 2020.
Resumo

Abstract In this work, the natural latex extracted from Harconia speciosa was incorporated with silver nanoparticles (AgNP) to compose a functional biomaterial associating the intrinsic angiogenic activity of the latex and the antimicrobial activity of AgNP. Tissue reaction after subcutaneous implantation in dorsum of rats of membranes without AgNP and with 0.05%, 0.4% AgNP was compared at 3, 7 and 25 days. No statistically significant difference in the tissue response of the different biomaterials was observed, indicating that AgNP did not interfere with the inflammatory reaction (p > 0.05) or with the angiogenic activity of latex. Biomembranes were also tested against bacterial biofilm formation by Staphylococcus aureus and the antimicrobial activity of the new biomaterial can be found with bacteria crenation (0.05% AgNP) and no biofilm deposition (0.4% AgNP). Therefore, this biomaterial has interesting properties for the tissue repair process and may be feasible for future applications as dressing. (AU)

Processo FAPESP: 16/06399-0 - Desenvolvimento e estudo da reação tecidual de um novo biomaterial composto de látex Hancornia speciosa Gomes e nanopartículas de prata
Beneficiário:Jéssica Mariana Bonete
Linha de fomento: Bolsas no Brasil - Iniciação Científica