Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Phenolic profile and potential beneficial effects of underutilized Brazilian native fruits on scavenging of ROS and RNS and anti-inflammatory and antimicrobial properties

Texto completo
Autor(es):
Soares, Jackeline Cintra [1] ; Rosalen, Pedro Luiz [2, 3] ; Lazarini, Josy Goldoni [2] ; Orlandi Sardi, Janaina de Cassia [4] ; Massarioli, Adna Prado [1] ; Nani, Bruno Dias [2] ; Franchin, Marcelo [2, 5] ; de Alencar, Severino Matias [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Luiz de Queiroz Coll Agr, Dept Agrifood Ind, Ave Padua Dias, BR-13418900 Piracicaba, SP - Brazil
[2] Univ Estadual Campinas, Dept Physiol Sci, Piracicaba Dent Sch, Ave Limeira 901, BR-13414018 Piracicaba, SP - Brazil
[3] Univ Fed Alfenas, Grad Program Biol Sci, Alfenas, MG - Brazil
[4] Univ Fed Mato Grosso, Sch Pharmaceut Sci Food & Nutr, Campo Grande, MS - Brazil
[5] Fed Univ Alfenas MG, Sch Dent, Unifal MG, Alfenas - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: FOOD & FUNCTION; v. 11, n. 10, p. 8905-8917, OCT 1 2020.
Citações Web of Science: 0
Resumo

Brazilian native fruits (BNF) have aroused interest of researchers and consumers for their great human health benefits. In this study, five BNF (Byrsonima lancifolia, Campomanesia phaea, Jacaratia spinosa, Solanum alternatopinnatum and Acnistus arborescens) were tested for their polyphenolic compounds by LC-ESI-MS/MS, reactive species deactivation (ROO\_, O2\_-, HOCl and NO\_), anti-inflammatory properties in vivo, and in vitro antimicrobial activity - with determination of putative mechanism(s) of action. Eightyone polyphenols were identified, which exhibited a significant capacity to deactivate both ROS and RNS. C. phaea extract had the highest capacity to scavenge ROO\_ (68.94 mu mol TE per g), O2\_- (IC50: 575.36 mu g mL-1) and NO\_ (IC50: 16.96 mu g mL-1), which may be attributed to the presence of ellagitanins. B. lancifolia decreased neutrophil influx into the peritoneal cavity of mice by 50% as compared to carrageenan and reduced Candida albicans biofilm viability by 3 log10 possibly due to complexation with cell membrane ergosterol. In summary, the BNF presented herein are good sources of bioactive compounds with positive effects on deactivation of biological reactive species, as well as with anti-inflammatory and antimicrobial activities, which can be altogether highly beneficial to human health. (AU)

Processo FAPESP: 17/09898-0 - Bioprospecção de novas moléculas anti-inflamatórias de produtos naturais nativos brasileiros
Beneficiário:Pedro Luiz Rosalen
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/02926-6 - Fitoquímica e bioprospecção de atividades antioxidante e anti-inflamatória de frutas nativas brasileiras inexploradas.
Beneficiário:Josy Goldoni Lazarini
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 13/13190-2 - Composição fenólica e potencial biológico, in vitro e in vivo, de frutíferas nativas do Brasil
Beneficiário:Severino Matias de Alencar
Linha de fomento: Auxílio à Pesquisa - Regular