| Texto completo | |
| Autor(es): |
Barbosa Toscano, Joao Henrique
[1]
;
Okino, Cintia Hiromi
[2]
;
Barbosa dos Santos, Isabella
[1]
;
Giraldelo, Luciana Aparecida
[3]
;
Borsch von Haehling, Marei
[1]
;
Novita Esteves, Sergio
[2]
;
Bassetto, Cesar Cristiano
[4]
;
Talamini do Amarante, Alessandro Francisco
[4]
;
de Souza Chagas, Ana Carolina
[2]
Número total de Autores: 9
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Paulista UNESP, Fac Ciencias Agr & Vet, Jaboticabal - Brazil
[2] Embrapa Pecuaria Sudeste, Sao Carlos - Brazil
[3] Ctr Univ Cent Paulista, Sao Carlos - Brazil
[4] Univ Estadual Paulista UNESP, Inst Biociencias, Botucatu, SP - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PARASITE IMMUNOLOGY; v. 42, n. 12 DEC 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Aims Local and systemic immune mediators of Morada Nova lambs with divergentHaemonchus contortusresistance phenotypes were evaluated. Methods and Results Lambs were ranked through faecal egg counts (FEC) after two parasitic challenges with 4,000H.contortusL(3). After the second challenge, the lambs underwent a third artificial infection and were euthanized 7 days later. Immune-related genes were quantified locally in abomasal mucosa and lymph nodes (CD4,IFN gamma,IL4,IL5,IL13,IL2RAandMS4A2) and systemically in the whole blood (IL4andIL13). Anti-H. contortusIgG and IgA antibodies and eosinophils and mast cells counts were also investigated. Resistant animals presented higher systemic IgG and IgA titres, both negatively correlated with FEC. Susceptible animals had higher blood levels ofIL4transcripts. At the local level, resistant lambs had higher eosinophils counts and superiorMS4A2levels in abomasal fundic mucosa, besides higher IgA levels in abomasal mucus, while susceptible lamb had superiorIL4expression in abomasal lymph nodes. Conclusion These data indicate that resistant lambs had an immune response mediated by antibody-mediated cytotoxicity. Also, the systemic humoral profile, particularly IgA isotype, seems to be a good resistance marker for Morada Nova sheep, as we found differences between groups even when FEC did not differ. (AU) | |
| Processo FAPESP: | 17/01626-1 - Caracterização genética e de respostas imunes associadas ao fenótipo de resistência parasitária em rebanho ovino da raça Morada Nova |
| Beneficiário: | Ana Carolina de Souza Chagas |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 17/24289-0 - Cordeiros Morada Nova: cuidados ao nascimento, avaliação dos níveis de infecção por nematoides gastrintestinais e seu impacto no ganho de peso |
| Beneficiário: | Luciana Aparecida Giraldelo |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 17/00373-2 - Caracterização de respostas imunes locais associadas ao fenótipo de resistência parasitária em cordeiros da raça morada nova |
| Beneficiário: | João Henrique Barbosa Toscano |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |