Long-Term Characterization of Hippocampal Remapping during Contextual Fear Acquisition and Extinction

Autor(es):Mostrar menos -

Schuette, Peter J. ^[1] ; Reis, V, Fernando M. C. ; Maesta-Pereira, Sandra ^[2] ; Chakerian, Meghmik ^[2] ; Torossian, Anita ^[2] ; Blair, Garrett J. ^[2] ; Wang, Weisheng ^[2] ; Blair, Hugh T. ^[2] ; Fanselow, Michael S. ^[2] ; Kao, Jonathan C. ^[3] ; Adhikari, Avishek ^[2]

Afiliação do(s) autor(es)

^[1] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 - USA

^[2] Reis, Fernando M. C., V, Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 - USA

^[3] Univ Calif Los Angeles, Dept Elect & Comp Engn, Los Angeles, CA 90095 - USA

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF NEUROSCIENCE; v. 40, n. 43, p. 8329-8342, OCT 21 2020.
• Citações Web of Science: 0

Resumo

Hippocampal CA1 place cell spatial maps are known to alter their firing properties in response to contextual fear conditioning, a process called ``remapping.{''} In the present study, we use chronic calcium imaging to examine remapping during fear retrieval and extinction of an inhibitory avoidance task in mice of both sexes over an extended period of time and with thousands of neurons. We demonstrate that hippocampal ensembles encode space at a finer scale following fear memory acquisition. This effect is strongest near the shock grid. We also characterize the long-term effects of shock on place cell ensemble stability, demonstrating that shock delivery induces several days of high fear and low between-session place field stability, followed by a new, stable spatial representation that appears after fear extinction. Finally, we identify a novel group of CA1 neurons that robustly encode freeze behavior independently from spatial location. Thus, following fear acquisition, hippocampal CA1 place cells sharpen their spatial tuning and dynamically change spatial encoding stability throughout fear learning and extinction. (AU)

• Processo FAPESP: 14/05432-9 - Bases neurais do medo e agressão
• Beneficiário: Newton Sabino Canteras
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/08668-1 - Estudo in vivo de populações neuronais GABAérgicas e glutamatérgicas da substância cinzenta periaquedutal em resposta a diferentes tipos de ameaça
• Beneficiário: Fernando Midea Cuccovia Vasconcelos Reis
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 15/23092-3 - Investigação das vias de sinalização envolvidas na formação da memória de medo em animais expostos ao predador
• Beneficiário: Fernando Midea Cuccovia Vasconcelos Reis
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado