Advances in Fungal Peptide Vaccines

Autor(es)

Da Silva, Leandro B. R. ^{[1, 2, 3]} ; Taborda, Carlos P. ^{[1, 4]} ; Nosanchuk, Joshua D. ^{[2, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508000 Sao Paulo - Brazil

^[2] Albert Einstein Coll Med, Div Infect Dis, Dept Med, New York, NY 10461 - USA

^[3] Albert Einstein Coll Med, Div Infect Dis, Dept Microbiol & Immunol, New York, NY 10461 - USA

^[4] Univ Sao Paulo, Fac Med, Dept Dermatol, Inst Med Trop Sao Paulo, Lab Micol Med, BR-05403000 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF FUNGI; v. 6, n. 3 SEP 2020.
• Citações Web of Science: 0

Resumo

Vaccination is one of the greatest public health achievements in the past century, protecting and improving the quality of life of the population worldwide. However, a safe and effective vaccine for therapeutic or prophylactic treatment of fungal infections is not yet available. The lack of a vaccine for fungi is a problem of increasing importance as the incidence of diverse species, including Paracoccidioides, Aspergillus, Candida, Sporothrix, and Coccidioides, has increased in recent decades and new drug-resistant pathogenic fungi are emerging. In fact, our antifungal armamentarium too frequently fails to effectively control or cure mycoses, leading to high rates of mortality and morbidity. With this in mind, many groups are working towards identifying effective and safe vaccines for fungal pathogens, with a particular focus of generating vaccines that will work in individuals with compromised immunity who bear the major burden of infections from these microbes. In this review, we detail advances in the development of vaccines for pathogenic fungi, and highlight new methodologies using immunoproteomic techniques and bioinformatic tools that have led to new vaccine formulations, like peptide-based vaccines. (AU)

• Processo FAPESP: 16/08730-6 - Patogenicidade fúngica: efeito do tabagismo, resposta imune e a modulação vacinal na paracoccidioidomicose e na histoplasmose
• Beneficiário: Carlos Pelleschi Taborda
• Linha de fomento: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/20622-2 - Prospecção de novos epítopos antigênicos de isolados de P. lutzii com potencial vacinal
• Beneficiário: Leandro Buffoni Roque da Silva
• Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 18/25171-6 - Prospecção de novos epitopos com potencial vacinal no controle da infecção experimental por Paracoccidioides lutzii
• Beneficiário: Leandro Buffoni Roque da Silva
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado