Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence?

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de Araujo, Celia Maria ^{[1, 2]} ; Swardfager, Walter ^{[3, 4]} ; Zugman, Andre ^{[1, 2]} ; Cogo-Moreira, Hugo ^[1] ; Belangero, Sintia I. ^{[5, 1, 2]} ; Ota, Vanessa K. ^{[5, 2]} ; Spindola, Leticia M. ^{[5, 2]} ; Hakonarson, Hakon ^[6] ; Pellegrino, Renata ^[6] ; Gadelha, Ary ^{[1, 2]} ; Salum, Giovanni A. ^{[7, 1]} ; Pan, Pedro M. ^{[1, 2]} ; Mansur, Rodrigo B. ^{[8, 9]} ; Hoexter, Marcelo ^{[10, 1]} ; Picon, Felipe ^{[7, 1]} ; Sato, Joao R. ^{[1, 11]} ; Brietzke, Elisa ^[2] ; Grassi-Oliveira, Rodrigo ^[12] ; Rohde, Luis A. P. ^{[7, 1]} ; Miguel, Euripedes C. ^{[8, 1]} ; Bressan, Rodrigo A. ^[1] ; Jackowski, Andrea P. ^{[1, 2]}

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^[1] Natl Inst Dev Psychiat Children & Adolescent INCT, Sao Paulo - Brazil

^[2] Queens Univ, Sch Med, Dept Psychiat, Kingston, ON - Canada

^[3] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON - Canada

^[4] Sunnybrook Res Inst, Hurvitz Brain Sci Program, Toronto, ON - Canada

^[5] Univ Fed Sao Paulo, Dept Morphol & Genet, Sao Paulo - Brazil

^[6] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 - USA

^[7] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Dept Psychiat, Porto Alegre, RS - Brazil

^[8] Univ Toronto, Dept Psychiat, Toronto, ON - Canada

^[9] Univ Toronto, Mood Disorders Psychopharmacol Unit, Toronto, ON - Canada

^[10] Univ Sao Paulo, Dept & Inst Psychiat, Sao Paulo - Brazil

^[11] Univ Fed ABC, Math & Stat Inst, Santo Andre, SP - Brazil

^[12] Pontif Catholic Univ Rio Grande Do Sul, Dev Cognit Neurosci Lab DCNL, Porto Alegre, RS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CNS SPECTRUMS; v. 25, n. 6, p. 790-796, DEC 2020.
• Citações Web of Science: 0

Resumo

Objective Mental disorders can have a major impact on brain development. Peripheral blood concentrations of brain-derived neurotrophic factor (BDNF) are lower in adult psychiatric disorders. Serum BDNF concentrations and BDNF genotype have been associated with cortical maturation in children and adolescents. In 2 large independent samples, this study tests associations between serum BDNF concentrations, brain structure, and psychopathology, and the effects of BDNF genotype on BDNF serum concentrations in late childhood and early adolescence. Methods Children and adolescents (7-14 years old) from 2 cities (n = 267 in Porto Alegre; n = 273 in Sao Paulo) were evaluated as part of the Brazilian high-risk cohort (HRC) study. Serum BDNF concentrations were quantified by sandwich ELISA. Genotyping was conducted from blood or saliva samples using the SNParray Infinium HumanCore Array BeadChip. Subcortical volumes and cortical thickness were quantified using FreeSurfer. The Development and Well-Being Behavior Assessment was used to identify the presence of a psychiatric disorder. Results Serum BDNF concentrations were not associated with subcortical volumes or with cortical thickness. Serum BDNF concentration did not differ between participants with and without mental disorders, or between Val homozygotes and Met carriers. Conclusions No evidence was found to support serum BDNF concentrations as a useful marker of developmental differences in brain and behavior in early life. Negative findings were replicated in 2 of the largest independent samples investigated to date. (AU)

• Processo FAPESP: 14/07280-1 - Busca por marcadores genéticos de risco, de progressão e de reposta ao tratamento na esquizofrenia
• Beneficiário: Síntia Iole Nogueira Belangero
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/08531-5 - Coorte de alto risco para transtornos psiquiátricos na infância: seguimento de neuroimagem após 3 anos
• Beneficiário: Andrea Parolin Jackowski
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/04983-7 - Neuroimagem, genômica, transcriptômica e epigenômica: conduzindo análises em larga escala em direção a um modelo integrativo de transtornos mentais
• Beneficiário: Jair de Jesus Mari
• Modalidade de apoio: Auxílio à Pesquisa - Programa eScience e Data Science - Regular
• Processo FAPESP: 14/50917-0 - INCT 2014: psiquiatria do desenvolvimento para crianças e adolescentes
• Beneficiário: Eurípedes Constantino Miguel Filho
• Modalidade de apoio: Auxílio à Pesquisa - Temático