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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Predictive factors for the development of anemia after hematopoietic stem cell donation

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Autor(es):
Steuer, Lia V. [1] ; Kondo, Andrea T. [1] ; Cipolletta, Andrea N. [1] ; Sakashita, Araci M. [1] ; Hamerschlak, Nelson [1] ; Kutner, Jose M. [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Hosp Israelita Albert Einstein, Hemotherapy & Cell Therapy Dept, Av Albert Einstein 627, Banco Sangue, Bloco A-3, BR-05651901 Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Transfusion; v. 61, n. 1, p. 159-166, JAN 2021.
Citações Web of Science: 0
Resumo

Background Although Hematopoietic Stem Cells (HSC) donation through bone marrow (BM) and peripheral blood (PB) are usually safe procedures, adverse events are expected. One of the most common events especially among BM donors (BMD) is the development of anemia. To protect the BMD and preserve the hemoglobin levels, many centers collect autologous pre-procedure blood, but the actual benefits of this procedure is controversial. Methods and Materials This study analyzed retrospectively data to observe what factors may influence the occurrence of post-donation anemia and also evaluate the relevance of autologous red blood cell pre procedure donation (PAD). Results The development of immediately post donation anemia (IP) was higher in BMD than in PB donors (64.2% BMD and 10.7% PBD,P< .001) and also in late post donation (LP) (28.4% BMD and 3.6% PBD,P= .007). The study demonstrated an association between PAD and anemia in IP (72.7% with anemia and 27.3% without anemia,P= .006) and an association between the volume of red blood cells in the donated hematopoietic product and the development of anemia in LP (356.3 mL and 297.8 mL,P= .037). Conclusion In conclusion, collection of HSC through BM is a risk factor for anemia and PAD is a risk factor for IP anemia. (AU)

Processo FAPESP: 17/05694-1 - Fatores preditivos para o desenvolvimento de anemia pós doação de células tronco hematopoiéticas
Beneficiário:Lia Vineyard Steuer
Linha de fomento: Bolsas no Brasil - Iniciação Científica