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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Swimming Program on Mildly Diabetic Rats in Pregnancy

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Autor(es):
Macedo, Nathalia C. D. [1] ; Iessi, Isabela L. [1] ; Gallego, Franciane Q. [1] ; Netto, Aline O. [1] ; Sinzato, Yuri K. [1] ; Volpato, Gustavo T. [2] ; Zambrano, Elena [3] ; Damasceno, Debora C. [4]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Southwest Paulista Univ Ctr Unifsp, Botucatu, SP - Brazil
[2] Fed Univ Mato Grosso UFMT, Inst Biol & Hlth Sci, Lab Syst Physiol & Reprod Toxicol, Barra Do Garcas, MG - Brazil
[3] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Biol Reprod, Mexico City, DF - Mexico
[4] Paulo State Univ UNESP, Botucatu Med Sch, Postgrad Program Tocogynecol, Lab Expt Res onGynecol & Obstet, Botucatu, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: REPRODUCTIVE SCIENCES; v. 28, n. 8 JAN 2021.
Citações Web of Science: 1
Resumo

The present study aims to confirm if the moderate-intensity swimming has successful glycemic control and non-toxic oxidative stress levels and to verify the influence on pancreatic adaptations, embryo implantation, and placental efficiency. Female Wistar rats were randomly distributed to obtain mildly diabetic by streptozotocin induction at birth and the non-diabetic females given vehicle. At adulthood, pregnant rats were put at random into sedentary non-diabetic rats (ND); exercise non-diabetic rats (NDEx); sedentary diabetic rats (D); and exercise diabetic rats (DEx). The rats of the groups submitted to moderate intensity carried loads equivalent to 4% of body weight. On day 17 of gestational day, all rats were submitted to oral glucose tolerance test (OGTT). Next day (GD18), the rats were anesthetized and killed to count implantation sites and to collect placentas, blood, and muscle samples for biochemical biomarkers and pancreas for immunohistochemical analysis. The moderate exercise used was not sufficient to stimulate the aerobic pathway but presented positive results on glucose metabolism, lower embryo postimplantation loss, and pancreatic morphology compared with the sedentary diabetic group. However, the DEx group showed muscular damage, decreased antioxidant defense, and lipid peroxidation. Thus, the moderate-intensity exercise reduces glycemic levels during OGTT and causes no damage to non-diabetic rats related to other analyzed parameters in this study. The exercised diabetic rats present better glycemic metabolism in OGTT, islet pancreatic morphology, and embryofetal development. However, it is necessary an adjustment in this exercise intensity to improve the effectiveness of aerobic training for reduction of maternal muscular and lipid membrane damages. (AU)

Processo FAPESP: 13/23478-3 - Avaliação da prática de exercício físico (natação) de intensidade moderada no estresse oxidativo, hormônios sexuais e proliferação pancreática de ratas diabéticas prenhes
Beneficiário:Nathália Cristine Dias de Macedo
Linha de fomento: Bolsas no Brasil - Mestrado