Exercise Training as Therapeutic Approach in Cancer Cachexia: A Review of Potential Anti-inflammatory Effect on Muscle Wasting

Autor(es)

Leal, Luana G. ^{[1, 2]} ; Lopes, Magno A. ^[3] ; Peres, Sidney B. ^[4] ; Batista, Jr., Miguel L. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Mogi Das Cruzes, Integrated Grp Biotechnol, Lab Adipose Tissue Biol, Mogi Das Cruzes, SP - Brazil

^[2] Univ Mogi Das Cruzes, Technol Res Grp, Mogi Das Cruzes, SP - Brazil

^[3] Czech Acad Sci, Inst Physiol, Lab Metab Bioact Lipids, Prague - Czech Republic

^[4] Univ Estadual Maringa, Dept Physiol Sci, Maringa, Parana - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: FRONTIERS IN PHYSIOLOGY; v. 11, FEB 4 2021.
• Citações Web of Science: 0

Resumo

Cachexia is a multifactorial inflammatory syndrome with high prevalence in cancer patients. It is characterized by a metabolic chaos culminating in drastic reduction in body weight, mainly due to skeletal muscle and fat depletion. Currently, there is not a standard intervention for cachexia, but it is believed that a dynamic approach should be applied early in the course of the disease to maintain or slow the loss of physical function. The present review sought to explain the different clinical and experimental applications of different models of exercise and their contribution to a better prognosis of the disease. Here the advances in knowledge about the application of physical training in experimental models are elucidated, tests that contribute substantially to elucidate the cellular and biochemical mechanisms of exercise in different ways, as well as clinical trials that present not only the impacts of exercise in front cachexia but also the challenges of its application in clinical practice. (AU)

• Processo FAPESP: 18/20905-1 - TLR4 como crossroad da inflamação e metabolismo energético: Papel do tecido adiposo na síndrome de caquexia
• Beneficiário: Miguel Luiz Batista Junior
• Modalidade de apoio: Bolsas no Exterior - Pesquisa
• Processo FAPESP: 15/19259-0 - Repercussões do remodelamento do tecido adiposo durante a síndrome de caquexia em pacientes com câncer gastrointestinal: potencial envolvimento do receptor TLR4 na modulação do browning no TAB
• Beneficiário: Miguel Luiz Batista Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular