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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

5-Fluorouracil, innovative drug delivery systems to enhance bioavailability for topical use

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Autor(es):
de Oliveira, Beatriz Ewert [1] ; Junqueira Amorim, Otavio Henrique [2] ; Lima, Loneta Lauro [2] ; Rezende, Rodrigo Alvarenga [2, 3] ; Mestnik, Natalia Cammarosano [4] ; Bagatin, Edileia [4] ; Leonardi, Gislaine Ricci [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Campinas UNICAMP, Sch Pharmaceut Sci, Campinas, SP - Brazil
[2] Renato Archer Informat Technol Ctr CTI, Campinas, SP - Brazil
[3] Univ Araraquara Uniara, Postgrad Program Biotechnol, Araraquara, SP - Brazil
[4] Fed Univ Sao Paulo UNIFESP, Dept Dermatol, Sao Paulo, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo de Revisão
Fonte: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY; v. 61, FEB 2021.
Citações Web of Science: 0
Resumo

Background: 5-Fluorouracil (5-FU) is a well-known chemotherapy drug, used for over 70 years in the treatment of several types of cancer. Topically, 5-FU has shown potential effect to treat premalignant and malignant lesions. However, the efficiency of topical 5-FU administration is limited to treat superficial pre-carcinogenic lesions. Objective: In this review we present the main characteristics of 5-FU, including its mechanism of action, dissolution, and bioavailability. Moreover, we highlight the delivery systems under development that include 5-FU carriers in topical treatments. Results: Microemulsions and nanocarriers have demonstrated significant impact on the bioavailability of 5-FU in vitro and in vivo, increasing the drug effects on deeper layers of the skin, which has shown promising results in the treatment of precancemus and cancerous lesions. According to authors of clinical pilot studies, 5-FU occlusive dressing, 5-FU chemowrap, 5-FU transdermal, and their combination, resulting in a triple therapy, are more effective compared with cream formulation to treat precancer widespread in a skin area. Conclusion: Thus, by this review, we demonstrate that the delivery system under consideration greatly impacts 5-FU effects on the skin. (AU)

Processo FAPESP: 18/20366-3 - Efeito da emulsão clássica de 5-fluorouracil versus 5-fluorouracil manipulado em emulsão com polímero hidrofílico e homogeneização de alta velocidade no campo de cancerização e no fotoenvelhecimento avançado
Beneficiário:Ediléia Bagatin
Modalidade de apoio: Auxílio à Pesquisa - Regular