Bioactive Biofllavonoids from Platonia insignis (Bacuri) Residues as Added Value Compounds

Autor(es):Mostrar menos -

Ribeiro, Dayane C. ^{[1, 2]} ; Russo, Helena M. ^[1] ; Fraige, Karina ^[1] ; Zeraik, Maria L. ^[3] ; Nogueira, Claudio R. ^[4] ; da Silva, Patricia B. ^[5] ; Codo, Ana C. ^[6] ; Calixto, Giovana M. F. ^[2] ; de Medeiros, Alexandra I. ^[6] ; Chorilli, Marlus ^[2] ; Bolzani, Vanderlan S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista Julio de Mesquita Filho Un, Inst Quim, Dept Quim Organ, Nucleo Bioensaios Biossintese & Ecofisiol Prod Na, BR-14800900 Araraquara, SP - Brazil

^[2] Univ Estadual Paulista Julio de Mesquita Filho Un, Fac Ciencias Farmaceut, Dept Farmacos & Med, BR-14800903 Araraquara, SP - Brazil

^[3] Univ Estadual Londrina UEL, Dept Quim, Lab Fitoquim & Biomol LabFitoBio, BR-86051990 Londrina, PR - Brazil

^[4] Univ Fed Grande Dourados UFGD, Fac Ciencias Exatas & Tecnol FACET, BR-79804970 Dourados, MS - Brazil

^[5] Univ Brasilia UnB, Dept Genet & Morfol, BR-70910970 Brasilia, DF - Brazil

^[6] Univ Estadual Paulista Julio de Mesquita Filho Un, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14800900 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 32, n. 4, p. 786-799, APR 2021.
• Citações Web of Science: 0

Resumo

Platonia insignis fruit, popularly known as bacuri, is traditionally used in folk medicine for its anti-inflammatory and antioxidant properties. Therefore, this study determined the chemical composition and biological activities of the bacuri's shell and seeds extracts, considered residues from its consumption and industrial uses. Four biflavonoids (GB-2a, GB-1a, morelloflavone, and volkensiflavone) were identified in the extracts by high-performance liquid chromatography-diode array detection (HPLC-DAD), liquid chromatography tandem mass spectrometry (LC-MS/MS), and liquid chromatography-solid phase extraction-nuclear magnetic resonance (LC-SPE-NMR) techniques. Morelloflavone was identified as the main compound in the shell ethyl acetate extract, being responsible for the high in vitro antioxidant (50% effective concentration (EC50) ranging from 8.0-10.5 mu g mL(-1) in different protocols), anti-glycant (80%), and moderate inhibition of nitric oxide (1.56 mu g mL(-1) for > 90% cell viability) activities. This extract showed promising in vivo anti-inflammatory activity evaluated through the paw edema protocol after its incorporation into a liquid-crystalline drug carrier system, reducing the edema by up to 31%. The results demonstrated the potential of the fruit for the development of drugs of natural origin and corroborated to add economic value to these discarded residues. (AU)

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