Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value Compounds

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Dayane C. Ribeiro ; Helena M. Russo ^[2] ; Karina Fraige ^[3] ; Maria L. Zeraik ^[4] ; Cláudio R. Nogueira ^[5] ; Patrícia B. da Silva ^[6] ; Ana C. Codo ^[7] ; Giovana M. F. Calixto ^[8] ; Alexandra I. de Medeiros ^[9] ; Marlus Chorilli ^[10] ; Vanderlan S. Bolzani ^[11]

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 32, n. 4, p. 786-799, 2021-03-29.

Resumo

Platonia insignis fruit, popularly known as bacuri, is traditionally used in folk medicine for its anti-inflammatory and antioxidant properties. Therefore, this study determined the chemical composition and biological activities of the bacuri’s shell and seeds extracts, considered residues from its consumption and industrial uses. Four biflavonoids (GB-2a, GB-1a, morelloflavone, and volkensiflavone) were identified in the extracts by high-performance liquid chromatography-diode array detection (HPLC-DAD), liquid chromatography tandem mass spectrometry (LC-MS/MS), and liquid chromatography-solid phase extraction-nuclear magnetic resonance (LC-SPE-NMR) techniques. Morelloflavone was identified as the main compound in the shell ethyl acetate extract, being responsible for the high in vitro antioxidant (50% effective concentration (EC50) ranging from 8.0-10.5 µg mL−1 in different protocols), anti-glycant (80%), and moderate inhibition of nitric oxide (1.56 µg mL−1 for > 90% cell viability) activities. This extract showed promising in vivo anti-inflammatory activity evaluated through the paw edema protocol after its incorporation into a liquid-crystalline drug carrier system, reducing the edema by up to 31%. The results demonstrated the potential of the fruit for the development of drugs of natural origin and corroborated to add economic value to these discarded residues. (AU)

• Processo FAPESP: 17/19870-6 - Efeito da fagocitose de células apoptóticas infectadas na ativação de macrófagos M1/M2
• Beneficiário: Alexandra Ivo de Medeiros
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/50926-0 - INCT 2014: biodiversidade e produtos naturais
• Beneficiário: Vanderlan da Silva Bolzani
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático
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• Beneficiário: Ana Campos Codo
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 13/07600-3 - CIBFar - Centro de Inovação em Biodiversidade e Fármacos
• Beneficiário: Glaucius Oliva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
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• Beneficiário: Cleslei Fernando Zanelli
• Modalidade de apoio: Auxílio à Pesquisa - Regular