Mitochondria-associated ER membranes in glucose homeostasis and insulin resistance

Autor(es)

Townsend, Logan K. ^[1] ; Brunetta, Henver S. ^{[2, 3]} ; Mori, Marcelo A. S. ^{[4, 5, 3]}

Afiliação do(s) autor(es)

^[1] Univ Guelph, Dept Human Hlth & Nutr Sci, Guelph, ON - Canada

^[2] Univ Fed Santa Catarina, Dept Physiol Sci, Florianopolis, SC - Brazil

^[3] Univ Estadual Campinas, Dept Biochem & Tissue Biol, Campinas - Brazil

^[4] Univ Estadual Campinas, Obes & Comorbid Res Ctr, Campinas - Brazil

^[5] Univ Estadual Campinas, Expt Med Res Cluster, Campinas - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM; v. 319, n. 6, p. E1053-E1060, DEC 2020.
• Citações Web of Science: 2

Resumo

Obesity and insulin resistance (IR) are associated with endoplasmic reticulum (ER) stress and mitochondrial dysfunction in several tissues. Although for many years mitochondrial and ER function were studied separately, these organelles also connect to produce interdependent functions. Communication occurs at mitochondria-associated ER membranes (MAMs) and regulates lipid and calcium homeostasis, apoptosis, and the exchange of adenine nucleotides, among other things. Recent evidence suggests that MAMs contribute to organelle, cellular, and systemic metabolism. In obesity and IR models, metabolic tissues such as the liver, skeletal muscle, pancreas, and adipose tissue present alterations in MAM structure or function. The purpose of this mini review is to highlight the MAM disruptions that occur in each tissue during obesity and IR and its relationship with glucose homeostasis and IR. We also discuss the current controversy that surrounds MAMs' role in the development of IR. (AU)

• Processo FAPESP: 17/01184-9 - CAMeLEOm: análise entre espécies dos efeitos metabólicos, na expectativa de vida e ômicas de miméticos de restrição dietética
• Beneficiário: Marcelo Alves da Silva Mori
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/21852-1 - Contribuição dos miRNAs do tecido adiposo sobre a função, metabolismo e remodelamento cardíaco
• Beneficiário: Henver Simionato Brunetta
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado