Antibodies to Der p 1 and Der p 2 in allergic patients

Autor(es)

Cruz, Renata Harumi ^[1] ; Ynoue, Leandro Hideki ^[1] ; Aranda, Carolina Sanchez ^[2] ; Sole, Dirceu ^[2] ; Condino Neto, Antonio ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci 4, Dept Immunol, Lab Human Immunol, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Div Allergy Clin Immunol & Rheumatol, Dept Pediat, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ALLERGOLOGIA ET IMMUNOPATHOLOGIA; v. 49, n. 2, p. 46-52, MAR-APR 2021.
• Citações Web of Science: 0

Resumo

Introduction and objectives: Atopic individuals are characterized by increased IgE production and Th2 response if exposed to certain antigens. It is known that the mother transfers anti mite antibodies to the fetus and newborn, IgG thru the placenta, and IgA thru breastfeeding, but it is not clear whether there is a protective mechanism mediated by them concerning the development of future allergies. This study aimed to compare the levels of IgA, IgG, and IgE antibodies specific to Der p 1 and Der p 2 between atopic and healthy individuals. Methods: Serum samples of 98 patients and 44 healthy controls were subjected to quantification for specific IgE, IgG, and IgA antibodies against Der p 1 and Der p 2 by ImmunoCap (R) and ELISA, and subjected to statistical analysis as indicated. Results: Atopic patients had higher serum levels of IgE, IgG, and IgA specific to Der p 1 and Der p 2. The correlation was more robust between IgE and IgG antibodies. Conclusions: Allergic patients produce higher levels of antibodies against Der p 1 and Der p 2 compared with healthy individuals. The mechanisms involved still require detailed studies. (C) 2021 Codon Publications. Published by Codon Publications. (AU)

• Processo FAPESP: 15/10532-5 - Avaliação da resposta imune em cocultura de DCs e linfócitos T na presença de Der p 1 e Der p 2 e/ou anticorpos específicos à Dermatophagoides pteronyssinus
• Beneficiário: Renata Harumi Cruz
• Modalidade de apoio: Bolsas no Brasil - Mestrado