Altered expression of genes related to innate antifungal immunity in the absence of galectin-3

Autor(es)

Rezende, Caroline Patini ^[1] ; Martins Oliveira Brito, Patricia Kellen ^[2] ; Pessoni, Andre Moreira ^[1] ; Da Silva, Thiago Aparecido ^[2] ; Goldman, Gustavo H. ^[3] ; Almeida, Fausto ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Cellular & Mol Biol, Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias Farmaceut, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: VIRULENCE; v. 12, n. 1, p. 981-988, JAN 1 2021.
• Citações Web of Science: 1

Resumo

Galectin-3 (Gal-3) is the most studied member of the animal galectin family, which comprises beta-galactoside-binding lectins and participates in several cellular events. Its expression in cells involved in innate and adaptive immunity is related to anti- and proinflammatory functions, signaling an important role in inflammatory, infectious, and tumorigenesis processes. Mice deficient in Gal-3 exhibit important phenotypes, but it is unclear whether these phenotypes reflect an impairment of the functions of this protein. Gal-3 plays an important role in modulating the immune response to different pathogenic microorganisms. However, the role of Gal-3 in immunity to infection is still poorly understood. Therefore, we investigated the effects of Gal-3 deletion on the expression of genes involved in the innate immune response in the lungs, spleens, and brains of Gal-3 KO mice. Gene profiling expression analysis suggested that Gal-3 deletion resulted in differentially modulated expression of the genes encoding beta-glucan, mannose and chitin-responsive pattern recognition receptors, signal transduction, inflammation, and phagocytosis. Our data thus suggest the importance of Gal-3 expression in the host innate immune system. (AU)

• Processo FAPESP: 16/25167-3 - Influência de galectina-3 no curso da infecção por Cryptococcus neoformans
• Beneficiário: Caroline Patini de Rezende
• Linha de fomento: Bolsas no Brasil - Mestrado
• Processo FAPESP: 16/03322-7 - Papel de galectina-3 na infecção por Cryptococcus neoformans
• Beneficiário: Fausto Bruno dos Reis Almeida
• Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores