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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Salivary BPIFA proteins are altered in patients undergoing hematopoietic cell transplantation

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Autor(es):
Innocentini, Lara Maria Alencar Ramos [1] ; Silva, Andreia Aparecida [2] ; Carvalho, Marco Antonio [2] ; Coletta, Ricardo D. [2] ; Correa, Maria Elvira Pizzigatti [3] ; Bingle, Lynne [4] ; Bingle, Colin D. [5] ; Vargas, Pablo Agustin [2] ; Lopes, Marcio Ajudarte [2]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Ribeirao Preto Sch Med, Dent & Stomatol Div, Clin Hosp, Ophthalmol Otolaryngol & Head & Neck Su, Ribeirao Preto - Brazil
[2] Univ Campinas FOP UNICAMP, Sch Dent Piracicaba, Dept Oral Diag, Piracicaba, SP - Brazil
[3] Univ Estadual Campinas, Hematol & Blood Transfus Ctr, Sao Paulo - Brazil
[4] Univ Sheffield, Sch Clin Dent, Dept Oral & Maxillofacial Pathol, Sheffield, S Yorkshire - England
[5] Univ Sheffield, Dept Infect & Immun, Acad Unit Resp Med, Sheffield, S Yorkshire - England
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: ORAL DISEASES; APR 2021.
Citações Web of Science: 0
Resumo

Objective The aim of this study was to evaluate the expression of BPIFA proteins in the saliva and salivary glands of hematopoietic cell transplant (HCT) patients. Material and Methods This longitudinal study included patients who had undergone autologous HCT (auto-HCT) and allogeneic HCT (allo-HCT), and unstimulated saliva was collected at three time points, with a fourth collection at oral chronic graft-versus-host disease (cGVHD) onset. BPIFA expression was analysed by Western blotting in saliva and immunostaining in the minor salivary glands of cGVHD patients. Results Auto-HCT patients showed increased levels of BPIFA1 (p = .021) and BPIFA2 at D+7 (p = .040), whereas allo-HCT group demonstrated decreased expression of BPIFA2 at D+8 (p = .002) and at D+80 (p = .001) and a significant association between BPIFA2 low levels and hyposalivation was observed (p = .02). BPIFA2 was significantly lower in the cGVHD patients when compared to baseline (p = .04). Conclusions The results of this study show distinct pattern of expression of BPIF proteins in both auto-HCT and allo-HCT recipients with decreased levels of BPIFA2 during hyposalivation and cGVHD. Further studies are necessary to elucidate these proteins mechanisms and their clinical implications in these groups of patients. (AU)

Processo FAPESP: 11/07853-3 - Avaliação da expressão de proteínas da família plunc em pacientes com DECH, TCTH, câncer de cabeça e pescoço
Beneficiário:Pablo Agustin Vargas
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/00711-9 - Estudo clínico laboratorial de pacientes que receberão quimioterapia
Beneficiário:Lara Maria Alencar Ramos Innocentini
Linha de fomento: Bolsas no Brasil - Doutorado