Effect of the Andean Geography and Climate on the Specialized Metabolism of Its Vegetation: The Subtribe Espeletiinae (Asteraceae) as a Case Example

Autor(es)

Padilla-Gonzalez, Guillermo E. ^{[1, 2]} ; Diazgranados, Mauricio ^[3] ; Da Costa, Fernando B. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Lab Pharmacognosy, AsterBioChem Res Team, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] Royal Bot Gardens, Jodrell Lab, Kew Rd, London TW9 3AB - England

^[3] Royal Bot Gardens, Millennium Seed Bank, Haywards Heath RH17 6TN, W Sussex - England

• Tipo de documento: Artigo Científico
• Fonte: METABOLITES; v. 11, n. 4 APR 2021.
• Citações Web of Science: 0

Resumo

The Andean mountains are `center stage' to some of the most spectacular examples of plant diversifications, where geographic isolation and past climatic fluctuations have played a major role. However, the influence of Andean geography and climate as drivers of metabolic variation in Andean plants is poorly elucidated. Here, we studied the influence of those factors on the metabolome of the subtribe Espeletiinae (Asteraceae) using liquid chromatography coupled to high-resolution mass spectrometry data of over two hundred samples from multiple locations. Our results demonstrate that metabolic profiles can discriminate Espeletiinae taxa at different geographic scales, revealing inter- and intraspecific metabolic variations: at the country level, segregation between Colombian and Venezuelan taxa was observed; regionally, between paramo massifs; and locally, between paramo complexes. Metabolic differences in Espeletiinae were mainly explained by geographic isolation, although differences in taxonomic genera, temperature, and elevation, were also important. Furthermore, we found that different species inhabiting the same paramo complex showed stronger chemical similarities than the same species at different locations, corroborating that geographic isolation represents the main driver of metabolic change in Espeletiinae. The current study serves as a starting point to fill in the gaps in how Andean geography and climate have shaped the metabolism of its vegetation and reveal the potential of untargeted metabolomics to study the environmental physiology of plants. (AU)

• Processo FAPESP: 16/21183-4 - Fingerprint metabólico e biossíntese de lactonas sesquiterpênicas em Smallanthus sonchifolius e Espeletia (Asteraceae): uma abordagem metabolômica e transcriptômica
• Beneficiário: Guillermo Federico Padilla Gonzalez
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 14/17702-0 - Metabolômica e evolução de caracteres químicos na subtribo Espeletiinae (Asteraceae)
• Beneficiário: Guillermo Federico Padilla Gonzalez
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 14/26866-7 - Metabolômica, alvos enzimáticos e ferramentas in silico na busca por substâncias bioativas de plantas
• Beneficiário: Fernando Batista da Costa
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/51454-3 - Estudos morfoanatômicos, metabolômicos e moleculares como subsídios à sistemática de espécies de Asteraceae e acesso ao seu potencial farmacológico
• Beneficiário: Beatriz Appezzato da Glória
• Modalidade de apoio: Auxílio à Pesquisa - Temático