Effects of physical activity on vascular function in autoimmune rheumatic diseases: a systematic review and meta-analysis

Autor(es)

Pecanha, Tiago ^{[1, 2]} ; Bannell, Daniel J. ^[3] ; Sieczkowska, Sofia Mendes ^{[1, 2]} ; Goodson, Nicola ^[4] ; Roschel, Hamilton ^{[1, 2]} ; Sprung, Victoria S. ^[3] ; Low, David A. ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med FMUSP, Appl Physiol & Nutr Res Grp, Sch Phys Educ & Sport, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med FMUSP, Lab Assessment & Conditioning Rheumatol, Rheumatol, Sao Paulo - Brazil

^[3] Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Liverpool, Merseyside - England

^[4] Liverpool Univ Hosp NHS Fdn Trust, Aintree Univ Hosp, Liverpool, Merseyside - England

• Tipo de documento: Artigo de Revisão
• Fonte: RHEUMATOLOGY; v. 60, n. 7, p. 3107-3120, JUL 2021.
• Citações Web of Science: 1

Resumo

Objectives. To summarize existing evidence and quantify the effects of physical activity on vascular function and structure in autoimmune rheumatic diseases (ARDs). Methods. Databases were searched (through March 2020) for clinical trials evaluating the effects of physical activity interventions on markers of micro- and macrovascular function and macrovascular structure in ARDs. Studies were combined using random effects meta-analysis, which was conducted using Hedges' g. Meta-analyses were performed on each of the following outcomes: microvascular function {[}i.e. skin blood flow or vascular conductance responses to acetylcholine (ACh) or sodium nitropusside (SNP) administration]; macrovascular function {[}i.e. brachial flow-mediated dilation (FMD%) or brachial responses to glyceryl trinitrate (GTN%); and macrovascular structure {[}i.e. aortic pulse wave velocity (PWV)]. Results. Ten studies (11 trials) with a total of 355 participants were included in this review. Physical activity promoted significant improvements in microvascular {[}skin blood flow responses to ACh, g=0.92 (95% CI 0.42, 1.42)] and macrovascular function {[}FMD%, g=0.94 (95% CI 0.56, 1.02); GTN%, g=0.53 (95% CI 0.09, 0.98)]. Conversely, there was no evidence for beneficial effects of physical activity on macrovascular structure {[}PWV, g=-0.41 (95% CI -1.13, 0.32)]. Conclusions. Overall, the available clinical trials demonstrated a beneficial effect of physical activity on markers of micro- and macrovascular function but not on macrovascular structure in patients with ARDs. The broad beneficial impact of physical activity across the vasculature identified in this review support its role as an effective non-pharmacological management strategy for patients with ARDs. (AU)

• Processo FAPESP: 19/15231-4 - Promoção de estilo de vida saudável em pacientes com Lúpus Eritematoso Sistêmico: efeitos sobre os riscos cardiometabólicos o ensaio clínico randomizado e controlado living well with Lupus
• Beneficiário: Sofia Mendes Sieczkowska
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/07150-4 - Quebra do tempo sedentário na artrite reumatoide: efeitos na função vascular
• Beneficiário: Tiago Peçanha de Oliveira
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 16/23319-0 - Disfunção autonômica cardiovascular em pacientes com artrite reumatoide: caracterização, associações com a doença e efeitos da interrupção do tempo sedentário
• Beneficiário: Tiago Peçanha de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado