Follow-up effects of transcranial direct current stimulation (tDCS) for the major depressive episode: A systematic review and meta-analysis

Autor(es)

Razza, Lais B. ^[1] ; De Smet, Stefanie ^{[2, 3]} ; Moffa, Adriano ^{[4, 5]} ; Sudbrack-Oliveira, Pedro ^[1] ; Vanderhasselt, Marie-Anne ^{[6, 2, 3]} ; Brunoni, Andre R. ^{[1, 7]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Serv Interdisciplinar Neuromodulacao, Clin Hosp, Lab Neurociencias LIM27, Dept & Inst Psiquiatria, Sao Paulo - Brazil

^[2] Ghent Expt Psychiat GHEP Lab, Ghent - Belgium

^[3] Univ Ghent, Ghent Univ Hosp, Dept Head & Skin Psychiat & Med Psychol, Ghent - Belgium

^[4] Black Dog Inst, Sydney, NSW - Australia

^[5] Univ New South Wales, Sch Psychiat, Sydney, NSW - Australia

^[6] Univ Ghent, Dept Expt Clin & Hlth Psychol, Ghent - Belgium

^[7] Univ Sao Paulo, Univ Sao Paulo & Hosp Univ, Dept Med Interna, Fac Med, Av Prof Lineu Prestes 2565, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: PSYCHIATRY RESEARCH; v. 302, AUG 2021.
• Citações Web of Science: 0

Resumo

Transcranial Direct Current Stimulation (tDCS) is an effective treatment during the acute phase of a major depressive episode (MDE), although the evidence for its follow-up efficacy is mixed. A systematic review and meta-analysis were performed. MEDLINE/PubMed, Scopus (EMBASE), Web of Science, Cochrane Library and additional sources were searched from inception to April 29, 2021. Studies that followed up adults treated with tDCS during an MDE - using (interventional) and/or not using (observational) tDCS in the follow-up period were included. The primary outcome was the Hedges' g for the follow-up depression scores. Small study effects and sources of heterogeneity were explored. 427 studies were retrieved and 11 trials (13 datasets, n = 311) were included, most presenting moderate bias. Results showed a follow-up depression improvement (k = 13, g = -0.81, 95% confidence interval {[}CI]: -1.28; -0.34, I-2 = 84.0%), which was probably driven by the interventional studies (k = 7, g = -1.12, 95% CI: -1.84; -0.40, I-2 = 87.1%). No predictor of response was associated with the outcome. No risk of publication bias was found. Significant between-study heterogeneity may have influenced the overall results. Our findings suggest that tDCS produces effects beyond the intervention period during MDEs. Maintenance sessions are advised in future research. (AU)

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