Effects of UV-filter Photostabilizers in the Photostability and Phototoxicity of Vitamin A Palmitate Combined with Avobenzone and Octyl Methoxycinnamate

Autor(es)

Scarpin, Marcela Silva ^[1] ; Kawakami, Camila Martins ^[1] ; Rangel, Karen Cristina ^[1] ; Pereira, Karina de Castro ^[1] ; Benevenuto, Carolina Gomes ^[1] ; Gaspar, Lorena Rigo ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Photochemistry and Photobiology; v. 97, n. 4, p. 700-709, JUL 2021.
• Citações Web of Science: 0

Resumo

A challenge for cosmetic and dermatologic products is to develop new high-performance and safer anti-aging products based on new compounds to enhance the stability of retinyl palmitate combined with broad-spectrum UV-filters. Consequently, the aim of this work was to evaluate the effects of three often used avobenzone photostabilizers-ethylhexyl methoxycrylene (EHMCR), tris(tetramethylhydroxypiperidinol) citrate (TTMHP) and tris-biphenyl triazine (TBPT)-on the photostability and phototoxicity of the combination of avobenzone (AVO), octyl methoxycinnamate (OMC) and retinyl palmitate (RP). The photostability studies were performed by the exposure of formulations to UVA radiation. The phototoxicity was evaluated by the 3T3 neutral red uptake phototoxic assay (OECD TG 432). The addition of EHMCR, TBPT, and TTMHP in the formulations, with/or without RP, improved the photostability of AVO and RP, but EHMCR was the most effective in stabilizing RP. In the phototoxicity assay, the combinations AVO-OMC containing or not RP showed phototoxic potential. EHMCR and TTMHP reduced the phototoxicity of the combination AVO-OMC, whereas EHMCR also decreased the phototoxicity of the combination containing RP. Therefore, EHMCR might be used to the photostabilization of formulations of AVO-OMC with/or not RP, while TTMHP can be added to this photounstable UV-filter combination. (AU)

• Processo FAPESP: 14/05491-5 - Modelos alternativos à experimentação animal para a avaliação do potencial fotossensibilizante de filtros solares
• Beneficiário: Lorena Rigo Gaspar Cordeiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/25851-1 - Influência da combinações entre repelentes de insetos e filtros solares em processos fotoinduzidos
• Beneficiário: Lorena Rigo Gaspar Cordeiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular