Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Gene signatures of autopsy lungs from obese patients with COVID-19

Texto completo
Autor(es):
Mostrar menos -
Santos e Silva, Juan Carlo [1] ; Vasconcelos, Amanda Pereira [1] ; Yonehara Noma, Isabella Harumi [1] ; Noronha, Natalia Yumi [2] ; Aquino, Rodrigo [1] ; Giddaluru, Jeevan [1, 3] ; Durao, Luiz [1] ; Costa-Martins, Andre Guilherme [1, 3] ; Schuch, Viviane [1] ; Moraes-Vieira, Pedro M. [4, 5] ; Nakaya, I, Helder
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] I, Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Sao Paulo - Brazil
[3] I, Univ Sao Paulo, Sci Platform Pasteur, Sao Paulo - Brazil
[4] Univ Estadual Campinas, Obes & Comorbid Res Ctr OCRC, Campinas, SP - Brazil
[5] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Lab Immunometab, Campinas - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: CLINICAL NUTRITION ESPEN; v. 44, p. 475-478, AUG 2021.
Citações Web of Science: 0
Resumo

Background \& aims: Obesity is associated with low grade systemic inflammation and insulin resistance. Although metabolic and immunological changes may contribute to the increased risk for COVID-19 mortality in obese, little is known about the impact of obesity in the lungs of patients with COVID-19. Methods: We analyzed gene expression profiles of autopsy lungs of a cohort of 14 COVID-19 patients and 4 control individuals. Patients were divided into 3 groups according to their comorbidities: hypertension, type 2 diabetes (T2D) and obesity. We then identified the molecular alterations associated with these comorbidities in COVID-19 patients. Results: Patients with only hypertension showed higher levels of inflammatory genes and B-cell related genes when compared to those with T2D and obesity. However, the levels of IFN-gamma, IL22, and CD274 (a ligand that binds to receptor PD1) were higher in COVID-19 patients with T2D and obesity. Several metabolic- and immune-associated genes such as G6PD, LCK and IL10 were significantly induced in the lungs of the obese group. Conclusion: Our findings suggest that SARS-CoV-2 infection in the lungs may exacerbate the immune response and chronic condition in obese COVID-19 patients. (C) 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 19/27139-5 - Aplicação de ferramentas genômicas para o estudo de bases de dados epidemiológicos
Beneficiário:Juan Carlo Santos e Silva
Linha de fomento: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 18/14933-2 - Biologia integrativa aplicada à saúde humana
Beneficiário:Helder Takashi Imoto Nakaya
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores - Fase 2
Processo FAPESP: 20/04579-7 - Estudo sobre fatores de risco associados à maior gravidade a COVID-19 e mapeamento de vias metabólicas necessárias para a resposta anti-SARS-CoV-2
Beneficiário:Pedro Manoel Mendes de Moraes Vieira
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 19/27146-1 - Integração de dados de transcriptoma com dados clínicos e imunológicos
Beneficiário:Amanda Pereira Vasconcelos
Linha de fomento: Bolsas no Brasil - Doutorado Direto