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Santos e Silva, Juan Carlo ^[1] ; Vasconcelos, Amanda Pereira ^[1] ; Yonehara Noma, Isabella Harumi ^[1] ; Noronha, Natalia Yumi ^[2] ; Aquino, Rodrigo ^[1] ; Giddaluru, Jeevan ^{[1, 3]} ; Durao, Luiz ^[1] ; Costa-Martins, Andre Guilherme ^{[1, 3]} ; Schuch, Viviane ^[1] ; Moraes-Vieira, Pedro M. ^{[4, 5]} ; Nakaya, I, Helder

Afiliação do(s) autor(es)

^[1] I, Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Sao Paulo - Brazil

^[3] I, Univ Sao Paulo, Sci Platform Pasteur, Sao Paulo - Brazil

^[4] Univ Estadual Campinas, Obes & Comorbid Res Ctr OCRC, Campinas, SP - Brazil

^[5] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Lab Immunometab, Campinas - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL NUTRITION ESPEN; v. 44, p. 475-478, AUG 2021.
• Citações Web of Science: 0

Resumo

Background \& aims: Obesity is associated with low grade systemic inflammation and insulin resistance. Although metabolic and immunological changes may contribute to the increased risk for COVID-19 mortality in obese, little is known about the impact of obesity in the lungs of patients with COVID-19. Methods: We analyzed gene expression profiles of autopsy lungs of a cohort of 14 COVID-19 patients and 4 control individuals. Patients were divided into 3 groups according to their comorbidities: hypertension, type 2 diabetes (T2D) and obesity. We then identified the molecular alterations associated with these comorbidities in COVID-19 patients. Results: Patients with only hypertension showed higher levels of inflammatory genes and B-cell related genes when compared to those with T2D and obesity. However, the levels of IFN-gamma, IL22, and CD274 (a ligand that binds to receptor PD1) were higher in COVID-19 patients with T2D and obesity. Several metabolic- and immune-associated genes such as G6PD, LCK and IL10 were significantly induced in the lungs of the obese group. Conclusion: Our findings suggest that SARS-CoV-2 infection in the lungs may exacerbate the immune response and chronic condition in obese COVID-19 patients. (C) 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 19/27139-5 - Aplicação de ferramentas genômicas para o estudo de bases de dados epidemiológicos
• Beneficiário: Juan Carlo Santos e Silva
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 18/14933-2 - Biologia integrativa aplicada à saúde humana
• Beneficiário: Helder Takashi Imoto Nakaya
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2
• Processo FAPESP: 20/04579-7 - Estudo sobre fatores de risco associados à maior gravidade a COVID-19 e mapeamento de vias metabólicas necessárias para a resposta anti-SARS-CoV-2
• Beneficiário: Pedro Manoel Mendes de Moraes Vieira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/27146-1 - Integração de dados de transcriptoma com dados clínicos e imunológicos
• Beneficiário: Amanda Pereira Vasconcelos
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto